Tag: <span>hypotension</span>

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Drug interaction causes hypotension

by Leigh Macmillan,  Vanderbilt University The commonly used muscle relaxant tizanidine can lower blood pressure. Tizanidine is metabolized by the enzyme CYP1A2, and concurrent use of tizanidine and a CYP1A2 inhibitor, such as ciprofloxacin, greatly increases tizanidine plasma concentrations. Despite package insert warnings, tizanidine and CYP1A2 inhibitors are commonly co-prescribed. Cecilia Chung, MD, and colleagues used...

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New Insights to Improve CAR T Cells’ Safety

Drugs approved to treat rheumatoid arthritis block cytokines, the molecules responsible for severe side effects from the immunotherapy, and reduce symptoms in mice. Chimeric antigen receptor, or CAR, T-cell therapy has proven itself to benefit some patients with leukemia, lymphoma, and other cancers when traditional treatments have failed to save them—even producing some long-term remissions...