by Leigh Macmillan, Vanderbilt University The commonly used muscle relaxant tizanidine can lower blood pressure. Tizanidine is metabolized by the enzyme CYP1A2, and concurrent use of tizanidine and a CYP1A2 inhibitor, such as ciprofloxacin, greatly increases tizanidine plasma concentrations. Despite package insert warnings, tizanidine and CYP1A2 inhibitors are commonly co-prescribed. Cecilia Chung, MD, and colleagues used...
Tag: <span>hypotension</span>
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New Insights to Improve CAR T Cells’ Safety
Drugs approved to treat rheumatoid arthritis block cytokines, the molecules responsible for severe side effects from the immunotherapy, and reduce symptoms in mice. Chimeric antigen receptor, or CAR, T-cell therapy has proven itself to benefit some patients with leukemia, lymphoma, and other cancers when traditional treatments have failed to save them—even producing some long-term remissions...