This study included preclinical experiments and use of bronchoalveolar cells from IPF patients UNIVERSITY OF ALABAMA AT BIRMINGHAM BIRMINGHAM, Ala. – Long-held dogma says lung fibrosis in diseases like idiopathic pulmonary fibrosis, or IPF, results from recurrent injury to alveolar epithelium that is followed by dysregulated repair. Research at the University of Alabama at Birmingham uproots that paradigm, and it suggests a possible treatment target for IPF. A....
Tag: <span>Idiopathic Pulmonary Fibrosis (IPF)</span>
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Mechanism of fibrosis development discovered
Idiopathic pulmonary fibrosis (IPF) is an incurable lung disease of unknown origin with limited treatment options. Research suggests that the signaling molecule WNT5A plays a key role in the pathogenic process. Now, a group of scientists from Helmholtz Center Munich, working with colleagues from the University of Denver, have taken a further step toward uncovering...
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Molecular pathway offers treatment targets for pulmonary fibrosis, related conditions
A chest radiograph of a patient with Idiopathic Pulmonary Fibrosis (IPF). A study led by investigators at Massachusetts General Hospital (MGH) and University Health Network (UHN) in Toronto has identified a molecular pathway that appears to be critical to the development of fibrosis – scarring and excessive tissue deposition that result from abnormal healing...