by Technical University Munich MYB regulates the expression of genes that are critical for the function and maintenance of exhausted T cells. a–c, Congenically marked Mybfl/flCd4Cre (Myb-cKO) and Cd4Cre (control) P14 T cells were adoptively transferred into naive recipient mice, which were then infected with LCMV-Docile. Splenic P14 subsets were sorted at 7 dpi and processed for bulk RNA-seq....
By Katherine J. Wu Getty; The Atlantic JANUARY 21, 2022 Even before Omicron hit the United States in full force, most of our bodies had already wised up to SARS-CoV-2’s insidious spike—through infection, injection, or both. By the end of October 2021, some 86.2 percent of American immune systems may have glimpsed the virus’s most infamous protein, according...
by University of California, San Francisco Credit: CC0 Public Domain UC San Francisco scientists have discovered a new way to control the immune system’s ‘natural killer’ (NK) cells, a finding with implications for novel cell therapies and tissue implants that can evade immune rejection. The findings could also be used to enhance the ability of cancer...
INNOVATION CENTER OF NANOMEDICINE LEFT: HYDROPHOBIC EPIRUBISIN IS CONJUGATED TO ONE END OF HYDROPHILIC POLYETHYLENE GLYCOL (PEG) CHAIN WITH ASPARTATE-HYDRAZIDE AS A LINKER. IN WATER, THIS MOLECULE IS SELF-ASSEMBLED TO FORM NANO-MICELLES (EPI/M). UPPER… view more CREDIT: 2020 INNOVATION CENTER OF NANOMEDICINE Summary: A nanomedicine-based strategy for chemo-immunotherapy (CIT) of glioblastoma (GBM), which has the...
OHIO STATE UNIVERSITY WEXNER MEDICAL CENTER LEAD AUTHOR PHILLIP POPOVIC IS, CHAIR OF THE OHIO STATE DEPARTMENT OF NEUROSCIENCE AND EXECUTIVE DIRECTOR OF OHIO STATE’S BELFORD CENTER FOR SPINAL CORD INJURY AND CENTER FOR BRAIN… view more CREDIT: THE OHIO STATE UNIVERSITY WEXNER MEDICAL CENTER COLUMBUS, Ohio – Research conducted at The Ohio State University...
by Marilynn Marchione In this Friday, June 12, 2020 file photo, a woman has blood drawn for COVID-19 antibody testing in Dearborn, Mich. Research published on Tuesday, July 21, 2020 suggests that antibodies the immune system makes to fight the new coronavirus may only last a few months in people with mild illness. (AP Photo/Paul...
by Albert Einstein College of Medicine To study the potentially lethal coronavirus, Albert Einstein College of Medicine scientists have turned a relatively harmless virus into a coronavirus “surrogate” that is much safer to work with. The research was described this month in Cell Host & Microbe. “Research on the ‘real’ coronavirus is limited by the...
UNIVERSITY OF FREIBURG FROM LEFT: SUSANA MINGUET, WOLFGANG SCHAMEL, FREDERIKE HARTL. view more CREDIT: PHOTO: LAURENZ HERR, ANJA SCHWÄBLE Unraveling a key motif: The T lymphocytes of the immune system work to destroy infected cells or cancer cells. To do so, they have to identify the threat: Molecules perceived as foreign – so-called antigens –...
Treatment with the PI3K/ CK1ε inhibitor umbralisib showed fewer immune-mediated adverse reactions compared to PI3K inhibitor therapy H. LEE MOFFITT CANCER CENTER & RESEARCH INSTITUTE TAMPA, Fla. — Chronic lymphocytic leukemia (CLL) is the most common leukemia in adults. One in four new leukemia cases are CLL. Early-stage CLL patients often do not require therapy,...
By Sally Robertson, B.Sc. Researchers at the University of California San Diego have conducted a study showing that both smoking and the use of e-cigarettes containing nicotine and flavorings may critically exacerbate inflammation in cases of coronavirus disease 2019 (COVID-19) and significantly worsen clinical outcomes. The use of e-cigs that do not contain nicotine or...
