by Liz Murphy, Massachusetts General Hospital Carcinogen-exposed cancer cells transform that nature of tumor-infiltrating macrophages from immunosuppressive (left) to immune activating agents (right), rendering the cancer immunogenic. Green color highlights macrophages and purple color is an immunosuppressive mark on macrophages. Credit: Dr. Mei Huang.While carcinogens are widely known to be perpetrators of cancer, a new study...
by Weill Cornell Medical College Cancer cell experiencing endoplasmic reticulum stress. Credit: Ella Marushchenko (2018) A protein commonly found at high levels in lung cancer cells controls a major immunosuppressive pathway that allows lung tumors to evade immune attack, according to a study led by researchers at Weill Cornell Medicine. The discovery could hasten the development of...
by Matthew Woodruff, The Conversation Credit: Unsplash/CC0 Public Domain For almost three years, scientists have raced to understand the immune responses in patients who develop severe COVID-19, with an enormous effort aimed at defining where healthy immunity ends and destructive immunity begins. In the early days of the COVID-19 pandemic, much attention focused on reports of harmful inflammation and so-called cytokine...
by Weill Cornell Medical College Illustration of human liver anatomy. Credit: Shutterstock When fat accumulates in the liver, the immune system may assault the organ. A new study from Weill Cornell Medicine researchers identifies the molecule that trips these defenses, a discovery that helps to explain the dynamics underlying liver damage that can accompany type 2...
by NYU Langone Health Pancreatic cancer cells (blue) growing as a sphere encased in membranes (red). Credit: National Cancer Institute Aerobic exercise reprograms the immune system to reduce pancreatic tumor growth and amplify the effects of immunotherapy, a new study finds. Published online in Cancer Cell June 2, the study provides new insight into how the mammalian immune...
by Monash University Increased concentration of short-chain fatty acids in stool and plasma following HAMSAB supplementation. A Acetate, propionate, and butyrate concentrations in stool (mM) and B plasma (μM). Overall significance determined by GEE and pairwise differences between timepoints by estimated marginal means and include a Tukey adjustment for multiple corrections. Colors indicate individual subjects....
JANUARY 17TH, 2022 CONN HASTINGS MEDICINE, NANOMEDICINE Researchers at the University of Pennsylvania School of Medicine have created a new coating for nanoparticles that can help to protect them from attacks by the immune system. The approach, which uses naturally occurring proteins that can inhibit the complement system, can significantly reduce immune destruction of nanoparticles, meaning that more...
