Tag: <span>immune cell development</span>

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Maturation instead of cell death: Defective signaling pathways disrupt immune cell development
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Maturation instead of cell death: Defective signaling pathways disrupt immune cell development

by University of Freiburg A) UMAP projection of composite healthy donor (HD) samples from CD19+ cells of tonsil (n=7) and spleen (n=7) analyzed by spectral flow cytometry. (B) Identification of primary populations in one representative HD spleen and tonsil. (C) Identification of populations in the naïve B cell gate (IgD+CD38low). (D) Identification of populations within the...

Gene critical to immune cell development identified
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Gene critical to immune cell development identified

Much of the three-dimensional architecture of the genome in antibody-producing immune cells is dependent on a gene called SMC3. When this gene is not working properly it can lead to improper immune cell development and to cancer, by disrupting how DNA is structured inside the cell nucleus, according to a team of researchers from Weill Cornell Medicine....