by Gladstone Institutes Zachary Steinhart (left) and Ralf Schmidt (right), scientists at the Gladstone-UCSF Institute of Genomic Immunology led by Alex Marson, engineered a new CRISPR-based pipeline to test every gene in the genome and rapidly discover genes that can be “turned on” in immune cells to enhance their functions. Credit: Michael Short/Gladstone Institutes CRISPR...
LA JOLLA INSTITUTE FOR IMMUNOLOGY IMAGE: VITAMIN C IS A KEY INGREDIENT FOR IMMUNE CELL FUNCTION CREDIT: LA JOLLA INSTITUTE FOR IMMUNOLOGY LA JOLLA, CA–You can’t make a banana split without bananas. And you can’t generate stable regulatory T cells without Vitamin C or enzymes called TET proteins, it appears. Regulatory T cells (Tregs) help...
by Linda Koffmar, Uppsala University Credit: Circulation Research (2021). DOI: 10.1161/CIRCRESAHA.120.318380 Cardiovascular disease, the most common cause of death, is the result of oxygen deprivation as blood perfusion to affected tissue is prevented. To halt the development of the disease and to promote healing, re-establishment of blood flow is crucial. Researchers at Uppsala University have now discovered that one of the...
Macrophages are white blood cells involved in a variety of biological functions, from destroying infectious pathogens to repairing damaged tissue. To carry out their different roles, macrophages must first be activated and transformed into different subtypes. However, the mechanisms that lead to macrophage activation are not fully understood. Now, researchers at Osaka University have identified a new...
