THE MOUNT SINAI HOSPITAL / MOUNT SINAI SCHOOL OF MEDICINE New York, NY (Sept. 12, 2022) — Mount Sinai researchers have made two important discoveries about the mechanism by which bladder cancer cells foil attacks from the immune system. The research, published in Cancer Cell in September, could lead to a new therapeutic option for patients with these...
Tag: <span>Immune cell</span>
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Cellular waste may supercharge immune cell function
by Van Andel Research Institute Credit: CC0 Public Domain The immune cells that protect us from infection and cancer seek out a wide array of fuel sources to power their function—including some long thought to be cellular waste products. The findings, published today in Cell Metabolism, lay the foundation for future personalized dietary recommendations designed to supercharge...
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Immune cell linked to better lung cancer survival
by King’s College London Experimental design and γδ T cell composition in lung tissues and NSCLCs. a, Overview of study design. Paired tumor regions (red) and NT lung tissues (blue) collected under the TRACERx Study were enzymatically digested to extract tissue/TILs. TILs were cryopreserved and thawed at a later date for flow cytometry ± RNA-seq. In parallel,...
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Recovery from muscle loss injuries hindered by immune cell conflicts
by Jim Lynch, University of Michigan Credit: CC0 Public Domain Tissues often fail to regenerate from traumatic muscle-loss injuries such as gunshot wounds and car accidents, and new research in mice from the University of Michigan sheds light on why. The findings suggest new treatment strategies that could eventually restore function and prevent limb loss....
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Ally and enemy? Scientists explore immune cell suspect in Alzheimer’s disease
by Bill Hathaway, Yale University Fig. 1: Characterization of microglia-like cells in mhCOs. a Schematic for generating mhCOs. 10% of PU.1-infected hESCs were mixed with 90% parental HES3 hESCs, and PU.1 priming and full induction were performed on day 2 and 18, respectively. b Expression of microglia-related genes from control hCOs and mhCOs (30-day and...
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Immune cell receptor and ligand regulation: A therapeutic avenue for inflammatory diseases
IMAGE: NEURAMINIDASE SUPPRESSES AUTOIMMUNE ARTHRITIS AND ENCEPHALOMYELITIS BY INHIBITING DENDRITIC CELL AND OSTEOCLAST ACTIVITY THROUGH REMOVAL OF SIALIC ACID, THEREBY EXPOSING ASIALO-BIANTENNARY N-GLYCAN (NA2) AND GENERATING INHIBITORY SIGNALS THROUGH DENDRITIC CELL IMMUNORECEPTOR (DCIR). CREDIT: YOICHIRO IWAKURA FROM TOKYO UNIVERSITY OF SCIENCE Immune cells play a key role in mediating inflammatory responses. Dysregulation in signaling mechanisms...
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Immune cell ‘hubs’ discovered hiding in tumors
by Sarah C. P. Williams, Broad Institute of MIT and Harvard In a subset of human colorectal tumors, immune cells such as activated and potentially tumor-reactive T cells (white, green, and magenta) are organized into “hubs” around malignant cells (blue) expressing molecules (yellow) that attract immune cells. Credit: Joshua Pirl, Vjola Jorgji, Linda Nieman, Jonathan Chen....
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Early lung cancer coopts immune cell into helping tumors invade the lungs
by The Mount Sinai Hospital Myeloid immune cells alongside red blood cells in an electron micrograph of human blood. Credit: National Cancer Institute Immune cells that normally repair tissues in the body can be fooled by tumors when cancer starts forming in the lungs and instead help the tumor become invasive, according to a surprising discovery reported...
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Yale study reveals battle formation of immune cell soldiers in skin
By Michael Irving May 09, 2021 A microscope image of immune cells (Langerhans cells in red, dendritic epidermal T cells in green) spreading out among the epithelial cells in the skinGreco Lab. The skin is the body’s first line of defense against potential infection, and new research has brought us closer to understanding how it...
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New 3-D maps reveal inner workings of immune cell gene expression
by La Jolla Institute for Immunology Enhancers serve as specific switches that turn on genes in a cell specific manner but it has been difficult to determine which switch is connected to which gene. Credit: Alex Fung The COVID-19 pandemic has highlighted how our small genetic differences can have a tremendous effect on how our bodies...