by Max Delbrück Center for Molecular Medicine Mutated T cells are unable to kill B cells (red) induced by the Epstein-Barr virus. This causes other immune cells to flow into the area of infection, thereby blocking a blood vessel (center). Credit: Elijah D. Lowenstein and Xun Li, K. Rajewsky Lab, Max Delbrück CenterSome hereditary genetic defects...
First study tracking how NK cells respond to the tumour microenvironment in real time discovered that stimulating the IL-15 pathway prevented the rapid loss of function and improved tumor controlPeer-Reviewed Publication UNIVERSITY OF BIRMINGHAM Some immune cells in our bodies see their ‘killer instinct’ restricted after entering solid tumours, according to new research. In a...
During infection, reversible switch permits flexible formation of memory T cells, long-lived blood cells that can remember pathogen encounters and respond upon reinfection.Peer-Reviewed Publication UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE/UW MEDICINE THIS MOVIE SHOWS A SINGLE NAIVE CD8 T CELL. A TYPE OF WHITE BLOOD CELL INVOLVED IN IMMUNITY ACTIVATING IN RESPONSE TO STIMULATION THROUGH...
By Michael Irving Scientists have supercharged immunotherapy by engineering CAR T cells that can produce their own “medicine” to keep them fighting in the hostile environment around tumors Depositphotos A new form of immunotherapy helps immune cells “armor” themselves against exhaustion by releasing their own medicine to keep them going in the fight against cancer. In...
by Dartmouth Health The association between immune cell composition and EAA for Horvath, Hannum, Pheno, and Zhang, DunedinPACE, and EpiTOC2 TNSC clocks across three age groups (0, 0–18, 18–99). Sex, chronological age, ancestry, and disease status were adjusted (*FDR < 0.05, **FDR < 0.01, ***FDR < 0.001). Credit: Aging Cell (2023). DOI: 10.1111/acel.14071When asked, “How old are you?” Most people measure by...
Published: August 3, 2023 11.01am EDT Authors Mary PhilipAssistant Professor of Medicine and Pathology, Vanderbilt University Michael RudloffMD-Ph.D. Candidate in Molecular Pathology and Immunology, Vanderbilt University This microscopy image shows a cytotoxic T cell (blue) attacking a cancer cell (green) by releasing toxic chemicals (red). Alex Ritter and Jennifer Lippincott Schwartz and Gillian Griffiths/National Institutes of...
by Massachusetts General Hospital Credit: Pixabay/CC0 Public Domain Current treatments for atrial fibrillation (AFib), a common heart condition characterized by fast and irregular beats that can lead to stroke and heart failure, have multiple side effects and are ineffective for preventing AFib recurrence. New research led by investigators at Massachusetts General Hospital (MGH) and published in Science reveals that certain immune...
JOSEP CARRERAS LEUKAEMIA RESEARCH INSTITUTE IMAGE: DR. GRÉGROIRE STIK, GROUP LEADER AT THE JOSEP CARRERAS LEUKAEMIA RESEARCH INSTITUTE CREDIT: PICTURE FROM THE JOSEP CARRERAS LEUKAEMIA RESEARCH INSTITUTE The immune system is one of the most complex parts of our body. It keeps us healthy by getting rid of parasites, viruses or bacteria, and by destroying damaged or cancer cells....
by The Mount Sinai Hospital The study revealed how certain immune cell interactions in tumors facilitate response to checkpoint blockade, pointing to potential new approaches to cancer immunotherapy. Credit: Magen et al., Nature Medicine Researchers at the Icahn School of Medicine at Mount Sinai have uncovered a trio of immune cells within tumor niches that are associated with...
by Ramona Czakert Franson, University of Alberta Credit: Pixabay/Pete Linforth. In the human central nervous system, there are tiny cells that—for most people, most of the time—provide important immune protection to the brain and spinal cord. Occasionally these microglia cells run terribly awry, leading to neurodegenerative diseases like multiple sclerosis and Alzheimer’s disease. But in a...
