by Massachusetts General Hospital Credit: Pixabay/CC0 Public Domain Current treatments for atrial fibrillation (AFib), a common heart condition characterized by fast and irregular beats that can lead to stroke and heart failure, have multiple side effects and are ineffective for preventing AFib recurrence. New research led by investigators at Massachusetts General Hospital (MGH) and published in Science reveals that certain immune...
JOSEP CARRERAS LEUKAEMIA RESEARCH INSTITUTE IMAGE: DR. GRÉGROIRE STIK, GROUP LEADER AT THE JOSEP CARRERAS LEUKAEMIA RESEARCH INSTITUTE CREDIT: PICTURE FROM THE JOSEP CARRERAS LEUKAEMIA RESEARCH INSTITUTE The immune system is one of the most complex parts of our body. It keeps us healthy by getting rid of parasites, viruses or bacteria, and by destroying damaged or cancer cells....
by The Mount Sinai Hospital The study revealed how certain immune cell interactions in tumors facilitate response to checkpoint blockade, pointing to potential new approaches to cancer immunotherapy. Credit: Magen et al., Nature Medicine Researchers at the Icahn School of Medicine at Mount Sinai have uncovered a trio of immune cells within tumor niches that are associated with...
by Ramona Czakert Franson, University of Alberta Credit: Pixabay/Pete Linforth. In the human central nervous system, there are tiny cells that—for most people, most of the time—provide important immune protection to the brain and spinal cord. Occasionally these microglia cells run terribly awry, leading to neurodegenerative diseases like multiple sclerosis and Alzheimer’s disease. But in a...
by Ludwig Maximilian University of Munich Study overview, upper airways viral loads, and antibody-mediated neutralization of SARS-CoV-2. a Schematic representation of the study design. Donors were sampled weekly for 1 month and then periodically until 6 months after initial presentation. b Longitudinal quantification of upper airways viral loads (UA-VLs) in patients with mild COVID-19 (n = 25) recruited during the first week...
UNIVERSITY OF ROCHESTER MEDICAL CENTER Immunotherapy, particularly CAR T-Cell treatment for cancer, is extending the lives of many patients. But sometimes the therapy randomly migrates to places it shouldn’t go, tucking into the lungs or other noncancerous tissue and causing toxic side effects. A University of Rochester/Wilmot Cancer Institute team discovered the molecule responsible for guiding...
by University of Chicago Credit: Pixabay/CC0 Public Domain More than 10 million people are sickened by tuberculosis (TB) globally each year, resulting in 1.5 million deaths. Yet, as many as two billion people are infected with Mycobaterium tuberculosis, the bacterium that causes tuberculosis, and are otherwise healthy and asymptomatic. Scientists who study TB look at those...
by American Society for Biochemistry and Molecular Biology Researchers engineered immune cells (NK-92) to anchor glycocalyx-editing (GE) enzymes on the surface. The modified immune cells were able to break through the glycocalyx armor of cancer cells. Credit: Sangwoo Park, Cornell University One of the ways that cancer cells hide from the body’s immune system is...
by Krista Conger, Stanford University MYC regulated St6galnac4 promotes display of the glycan disialyl-T. (A) Murine T-ALL cell surface sialic acids were quantified at various time points after doxycycline administration to turn off expression of the MYC transgene. Sialic acids were detected via oxidation with mild periodate treatment and subsequent labeling with an aminooxy-biotin probe...
by Instituto de Medicina Molecular Credit: Pixabay/CC0 Public Domain Muscle is able to regenerate through a process that involves multiple steps and players, including the immune system. As our organism ages, the muscles lose the capacity to regenerate. Now, a new study led by Joana Neves and Pedro Sousa-Victor, group leaders at the Instituto de...
