by Karolinska Institutet Progression rate of newly diagnosed ALS patients. ALS patients were stratified by the proportion of T cell subsets in the blood (A) and cerebrospinal fluid (B) at the time of diagnosis. The longitudinal evolution of ALS functional rating scale-revised (ALSFRS-R) in relation to the baseline categories of T cell subsets is plotted...
UNIVERSITY OF BRISTOL IMAGE: ILLUSTRATION SHOWING HOW MINIATURE ARTIFICIAL PROTOCELLS LOADED WITH ANTI-MICRORNA-223 CARGO CAN REPROGRAM CANCER-ASSOCIATED MACROPHAGES IN LARVAL AND ADULT ZEBRAFISH LEADING THEM TO BE MORE PRO-INFLAMMATORY AND THUS ABLE TO DRIVE MELANOMA SHRINKAGE CREDIT: PACO LOPEZ CUEVAS A new way of reprogramming our immune cells to shrink or kill off cancer cells...
by Jeff Hansen, University of Alabama at Birmingham Constitutive activation of JAK1/2 in IFNγR1KO melanoma cells. a Identification of a JAK1/2-centric network of activated protein tyrosine kinases in IFNγR1KO cells by kinomic analysis. Input nodes (kinases) with large blue circles around them and smaller red circles on the top right corner indicate increased activity in IFNγR1KO cells. Arrowheads denote...
by University of Minnesota Medical School Graphical abstract. Credit: Med (2022). DOI: 10.1016/j.medj.2022.07.008 University of Minnesota researchers and their collaborators at the National Cancer Institute (NCI) investigated the role of a new intracellular checkpoint gene in regulating T-cell function against solid tumors. Known as CISH, the team published results in Med that show the checkpoint gene plays a key...
by Boston University Credit: CC0 Public Domain The billions of immune cells that help protect us from diseases do amazing things, but sometimes they need a little boost. For decades, scientists have been trying to figure out ways to engineer living immune cells to better combat aggressive diseases, like cancer. One big, relatively recent advancement in...
by Cedars-Sinai Medical Center Credit: Pixabay/CC0 Public Domain Cedars-Sinai investigators have developed a method to help identify which human gut microbes are most likely to contribute to a slew of inflammatory diseases like obesity, liver disease, inflammatory bowel disease, cancer and some neurological diseases. The technique, described in the peer-reviewed journal Science Translational Medicine, uses a protein...
UNIVERSITY OF PITTSBURGH IMAGE: XIAOMING HU, M.D., PH.D. CREDIT: XIAOMING HU PITTSBURGH, Aug. 1, 2022 – A unique subset of white blood cells confers fast-acting and lasting protection against ischemic stroke in mice, University of Pittsburgh neurologists and immunologists reported in the Journal of Clinical Investigation today. This study identified a novel subset of CD8+ regulatory-like T cells, or...
by University of Bonn When T cells (blue-white sphere) fill up with energy in the form of ketone bodies (blue), they can fight viruses more effectively. Credit: © Chantal Wientjens, AG Prof. Wilhelm / University of Bonn In severe COVID-19 patients, metabolism produces insufficient amounts of certain energy-rich compounds called ketone bodies. However, these energy carriers...
by Michael Keller, ETH Zurich AM and Mo-derived cells in influenza-infected mice. FeMo-reconstituted Csf2ra-/- and WT mice were infected with IAV (20 pfu PR8) as depicted in Fig. 2A. Representative gates and dot plots of BAL AM and BMo-Mac are shown on d10 and d21 p.i. Data are representative of at least 3 independent experiments with...
By Rich Haridy July 03, 2022 A new study has found users of pod-based nicotine-salt e-cigarettes had markers of immune suppression not seen in users of other e-cigarette devices Depositphotos New research from the UNC School of Medicine has found users of nicotine-salt-containing pod and disposable e-cigarettes display unique markers of immune suppression not seen...
