by University of Pittsburgh In mice that express LAG3 (left image), accumulation of LAG3 at the immunological synapse in T cells lowers the pH, making conditions more acidic (green and blue) compared with less acidic (red) conditions in T cells from mice that do not express LAG3 (right image). Credit: Guy, C. et al. Nature Immunology (2022)...
by Cleveland Clinic Credit: CC0 Public Domain A computer model developed by Cleveland Clinic oncologist Timothy Chan, MD, Ph.D., and colleagues accurately predicts whether immune checkpoint blockade (ICB) will be effective in patients diagnosed with a wide variety of cancers. The forecasting tool, developed using machine learning, assesses multiple biological and clinical variables in an individual...
