by Cleveland Clinic Credit: CC0 Public DomainCleveland Clinic researchers analyzed genes and brain tissue of patients with Alzheimer’s and found that differences in brain immunometabolism—the interactions between the immune system and the ways cells create energy—may contribute to women’s increased risk for the disease and its severity. The findings, published in Alzheimer’s and Dementia, offer...
CELL PRESS IMAGE: THIS DIAGRAM SHOWS HOW NK CELL FUNCTION COULD IN THEORY RESULT IN THE RESOLUTION OF NEUROPATHIC PAIN IN THE CONTEXT OF PERIPHERAL NERVE INJURY BY DIRECTED CYTOTOXICITY AGAINST A NUMBER OF PATHOLOGICAL CELLULAR TARGETS. CREDIT: KIM ET AL./TRENDS IN NEUROSCIENCES In the midst of a global opioid epidemic, a team of scientists...
by Lancet Credit: Pixabay/CC0 Public Domain The VLA1553 vaccine candidate for chikungunya disease was generally well tolerated and produced an immune response in 99% (263/266) of participants, according to a phase 3 randomized controlled trial published in The Lancet. Because the study, VLA1553-301, was not conducted in regions where chikungunya is endemic, researchers were unable to investigate whether the vaccine protects against subsequent...
by The Scripps Research Institute A structural depiction of two HIV nanoparticle vaccines (E2p and I3-01v9) and a close-up of the Env proteins these nanoparticles display on their surfaces (HIV-1 BG505 UFO trimer). The vaccines are designed to have shorter sugars (or glycans) on the Env protein. Credit: Scripps Research A new HIV vaccine from Scripps Research has shown a significantly...
by Ludwig Maximilian University of Munich MFG-E8-eGFP detects PS+ apoptotic and PS+ EV-decorated cells in vivo. Credit: Proceedings of the National Academy of Sciences (2023). DOI: 10.1073/pnas.2210047120 As a major component of the immune system, T cells play a critical role in fighting off viral infections. A team led by Prof. Thomas Brocker and Jan Kranich...
by Noah Brown, Massachusetts General Hospital Credit: Cell (2023). DOI: 10.1016/j.cell.2023.02.033 Aging (senescent) cells, which stop dividing but don’t die, can accumulate in the body over the years and fuel chronic inflammation that contributes to conditions such as cancer and degenerative disorders. In mice, eliminating senescent cells from aging tissues can restore tissue balance and lead to an increased healthy...
This finding, detailed in a paper in the Journal of Experimental Medicine, and highlighted in a broader piece in the journal, could help lead to ways to control the retinoic acid response and therefore be used as a therapy or for vaccine development against infection or even to treat GI tumors. The study, conducted in mice, centers on...
BY ALEXANDER TIN MARCH 23, 2023 / 11:57 AM / CBS NEWS A key piece of the body’s immune response to COVID-19 looks to have been damaged in people who caught the disease before they were vaccinated, a study published this month found, resulting in a “major reduction” to part of the defense the body typically...
by University of Cambridge A transmission electron micrograph of SARS-CoV-2 virus particles (UK B.1.1.7 variant), isolated from a patient sample and cultivated in cell culture. Credit: NIAID Individuals who are obese may be more susceptible to severe COVID-19 because of a poorer inflammatory immune response, say Cambridge scientists. Scientists at the Cambridge Institute of Therapeutic...
by NIH/National Institute of Allergy and Infectious Diseases Scanning electron micrograph of Mycobacterium tuberculosis bacteria, which cause TB. Credit: NIAID A clinical trial testing a freeze-dried, temperature-stable experimental tuberculosis (TB) vaccine in healthy adults found that it was safe and stimulated both antibodies and responses from the cellular arm of the immune system. The Phase...
