DZNE – GERMAN CENTER FOR NEURODEGENERATIVE DISEASES Contrary to what has been generally assumed so far, a severe course of COVID-19 does not solely result in a strong immune reaction – rather, the immune response is caught in a continuous loop of activation and inhibition. Experts from Charité – Universitätsmedizin Berlin, the University of Bonn,...
Tag: <span>Immune system</span>
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Boosting immune system a potential treatment strategy for COVID-19
by Jim Dryden, Washington University School of Medicine in St. Louis Front-line health-care providers work with seriously ill COVID-19 patients in an intensive care unit at Barnes-Jewish Hospital in St. Louis. New research from scientists at Washington University School of Medicine suggests that the immune systems of such patients can’t do enough to protect them...
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TLK protein inhibition activates the innate immune system
by Institute for Research in Biomedicine – IRB Tousled-like kinases (TLKs) are a potential therapeutic target for cancer treatment due to their central role in DNA repair and replication. The latest work by IRB Barcelona’s Genomic Instability and Cancer Laboratory, led by Travis H. Stracker, concludes that TLK inhibition activates the innate immune system, a...
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Lung Link
Harvard Medical School researchers at Boston Children’s Hospital and Brigham and Women’s Hospital will soon begin testing an existing drug, dornase alfa, in patients with severe COVID-19 pneumonia and respiratory failure. The randomized, controlled clinical trial aims to enroll 60 adults and children over age 3 who require mechanical ventilation. Dornase alfa, also known as...
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Slowing down a ‘helper’ cell may someday make vaccines more effective for seniors
A surprising new concept for boosting the power of flu vaccines might also boost future COVID-19 vaccines CINCINNATI CHILDREN’S HOSPITAL MEDICAL CENTER UNDESIRED EXCESSIVE INTERLEUKIN-10 (IL-10) PRODUCTION IN AGED MICE COMES PRIMARILY FROM TFH CELLS, ACCORDING TO NEW FINDINGS PUBLISHED IN SCIENCE ADVANCES. THIS CHART SHOWS THAT WHEN THESE CELLS ARE STIMULATED… view more CREDIT:...
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Immunoprotein impairs Sars-Cov-2
An endogenous protein prevents the virus from fusing with host cells RUHR-UNIVERSITY BOCHUM STEPHANIE PFÄNDER IS LOOKING FOR GENES THAT INHIBIT CORONA VIRUSES. view more CREDIT: RUB, MARQUARD A protein produced by the human immune system can strongly inhibit corona viruses, including Sars-Cov-2, the pathogen causing Covid-19. An international team from Germany, Switzerland and the...
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Antiviral method against herpes paves the way for combatting incurable viral infections
by Lund University Researchers at Lund University in Sweden have discovered a new method to treat human herpes viruses. The new broad-spectrum method targets physical properties in the genome of the virus rather than viral proteins, which have previously been targeted. The treatment consists of new molecules that penetrate the protein shell of the virus...
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Driving immunometabolism to control lung infection
by Ciara O’shea, Trinity College Dublin When drugs to kill microbes are ineffective, host-directed therapy uses the body’s own immune system to deal with the infection. This approach is being tested in patients with COVID-19, and now a team of researchers at Trinity College Dublin has published a study showing how it might also work...
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New platform enables long-term tracking of stem cell-derived tissues after transplantation
ALPHAMED PRESS CO-AUTHORS SO GUN HONG, DVM, PH.D., AND CYNTHIA DUNBAR, M.D., OF THE NATIONAL HEART, LUNG, AND BLOOD INSTITUTE (NHLBI), PART OF THE NATIONAL INSTITUTES OF HEALTH.view more CREDIT: ALPHAMED PRESS Durham, NC – A new platform reported on today in STEM CELLS Translational Medicine (SCTM) will enable long-term tracking of cardiomyocytes produced from...
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New role for white blood cells in the developing brain
VIB (THE FLANDERS INSTITUTE FOR BIOTECHNOLOGY) Whether white blood cells can be found in the brain has been controversial, and what they might be doing used to be complete mystery. In a seminal study published in Cell, an international team of scientists led by Prof. Adrian Liston (VIB-KU Leuven, Belgium & Babraham Institute, UK) describe...