For the first time, researchers have identified that an immune cell subset called gamma delta T cells that may be causing and/or perpetuating the systemic inflammation found in normal aging in the general geriatric population and in HIV-infected people who are responding well to drugs (anti-retrovirals). Even with effective viral control, HIV-infected individuals are at...
Tag: <span>immune</span>
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Blood test could lead to cystic fibrosis treatment tailored to each patient
Researchers at Stanley Manne Children’s Research Institute at Ann & Robert H. Lurie Children’s Hospital of Chicago, and colleagues, used a blood test and microarray technology to identify distinct molecular signatures in children with cystic fibrosis. These patterns of gene expression ultimately could help predict disease severity and treatment response, and lead to therapies tailored to each patient‘s precise biology. Findings were published in Physiological Genomics. “Our findings pave the way...
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Hairy Coating Keeps Nanoparticles Safe from Immune System, Liver
Nanoparticles are seemingly a great way to treat tumors, but they’re so rapidly washed out by the bloodstream that few of the nanoparticles actually reach their targets. Researchers at Drexel University have now developed a surface treatment that gives nanoparticles a significant advantage to overcome the body’s filtration system and therefore make nanotherapies much more...
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Enhancing immune checkpoint inhibitor therapy using treatment combination
A combination of a novel inhibitor of the protein CK2 (Casein kinase 2) and an immune checkpoint inhibitor has dramatically greater antitumor activity than either inhibitor alone, according to research from The Wistar Institute that was published online in Cancer Research. Credit: The Wistar Institute Immune checkpoint inhibitors have been approved to treat several types...
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Team finds missing immune cells that could fight lethal brain tumors
Glioblastoma brain tumors can have an unusual effect on the body’s immune system, often causing a dramatic drop in the number of circulating T-cells that help drive the body’s defenses. Researchers at Duke Cancer Institute have tracked the missing T-cells in glioblastoma patients in the bone marrow, locked away and unable to function because of a...
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Researchers artificially generate immune cells integral to creating cancer vaccines
Study also identifies a flaw in a current cancer therapy in clinical trials THE MOUNT SINAI HOSPITAL / MOUNT SINAI SCHOOL OF MEDICINE (New York, NY – August 14, 2018)– For the first time, Mount Sinai researchers have identified a way to make large numbers of immune cells that can help prevent cancer reoccurrence, according to a...
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Scientists Create New Pill That Prevents You From Gaining Weight
Scientists may have just discovered the miracle pill to quash all miracle pills — one that could allow a person to eat whatever they want but never gain weight in the process. Scientists from Yale University have found a way to reshape the portals in the gut that process fat absorption into the body, flattening...
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Protein droplets keep neurons at the ready and immune system in balance
HOWARD HUGHES MEDICAL INSTITUTE Inside cells, where DNA is packed tightly in the nucleus and rigid proteins keep intricate transport systems on track, some molecules have a simpler way of establishing order. They can self-organize, find one another in crowded spaces, and quickly coalesce into droplets – like oil in water. IMAGE: IN THIS 3-D RECONSTRUCTION,...
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The immune system: T cells are built for speed
At TU Wien, immune cells are being examined using special microscopic methods, and this is causing previous ideas about the surface of T cells to be rethought. VIENNA UNIVERSITY OF TECHNOLOGY Without T cells, we could not survive. They are a key component of our immune system and have highly sensitive receptors on their surface...
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Human immune ‘trigger’ map paves way for better treatments
A discovery about how human cells are ‘triggered’ to undergo an inflammatory type of cell death could have implications for treating cancer, stroke and tissue injury, and immune disorders. IMAGE: A DISCOVERY ABOUT HOW HUMAN CELLS ARE 'TRIGGERED' TO UNDERGO AN INFLAMMATORY TYPE OF CELL DEATH COULD HAVE IMPLICATIONS FOR TREATING CANCER, STROKE AND TISSUE INJURY,...