The team from Marien Hospital and the department of Virology of Ruhr-Universität Bochum (RUB) as well as the Clinic for Infectious Diseases, the Clinic of Anesthesiology and the Institute for Virology of University Medicine Essen studied specific antibodies and T cells occurring in recovered, seriously ill and deceased Covid-19 patients. The researchers identified comparable immune...
Tag: <span>Immunity</span>
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Small change makes cancer vaccine more effective in animal tests
Tweaking the adenovirus spike protein induces a more robust immune reaction for a cancer vaccine against gastric, pancreatic, esophageal and colon malignancies in animal models. THOMAS JEFFERSON UNIVERSITY PHILADELPHIA – Jefferson researchers developing a cancer vaccine to prevent recurrences of gastric, pancreatic, esophageal and colon cancers have added a component that would make the vaccine...
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COVID-19 Vaccine Delivered via Nose Protects Susceptible Mice from Infection
Researchers from the Washington University School of Medicine in St. Louis have developed a nasal vaccine against the SARS-CoV-2 virus that effectively protects susceptible mice from developing symptoms after receiving a single dose. Given that infection often takes place via the nose, the vaccine was designed to be delivered intranasally. “We were happily surprised to...
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Gut microbes shape our antibodies before we are infected by pathogens
PROF. DR. RER. NAT. STEPHANIE GANAL-VONARBURG DEPARTMENT FOR BIOMEDICAL RESEARCH (DBMR), UNIVERSITY OF BERN, AND UNIVERSITY CLINIC OF VISCERAL SURGERY AND MEDICINE OF THE INSELSPITAL, UNIVERSITY HOSPITAL BERN view more CREDIT: COURTESY OF STEPHANIE GANAL-VONARBURG B cells are white blood cells that develop to produce antibodies. These antibodies, or immunoglobulins, can bind to harmful foreign...
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Immune cell steroids help tumours suppress the immune system, offering new immunotherapy targets
by Wellcome Trust Sanger Institute A study has revealed that tumors can evade the immune system by telling immune cells to produce immunosuppressive steroids. Researchers from the Wellcome Sanger Institute, Department of Pathology, University of Cambridge, and MRC Cancer Unit, discovered that immune T cells from mouse skin and breast tumors secrete steroids, and that...
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New study identifies 21 existing drugs that could treat COVID-19
by Sanford Burnham Prebys Medical Discovery Institute Discovery Institute, gestures to experimental assays that test for compounds that may treat COVID-19. Credit: Sanford Burnham Prebys Medical Discovery Institute A Nature study authored by a global team of scientists and led by Sumit Chanda, Ph.D., professor at Sanford Burnham Prebys Medical Discovery Institute, has identified 21...
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Neutralizing antibodies isolated from COVID-19 patients can quash SARS-CoV-2
Reviewed by Emily Henderson, B.Sc. Antibodies are formed to fight off an infection by neutralizing disease-causing microorganisms. Scientists across the globe are racing to study how antibodies can help suppress the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes the coronavirus disease (COVID-19). A team of researchers at Columbia University Irving Medical...
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2 immunotherapies merged into single, more effective treatment
Mouse study suggests strategy may work against variety of cancers WASHINGTON UNIVERSITY SCHOOL OF MEDICINE RESEARCHERS AT WASHINGTON UNIVERSITY SCHOOL OF MEDICINE IN ST. LOUIS HAVE COMBINED TWO TYPES OF IMMUNOTHERAPY INTO A SINGLE TREATMENT THAT MAY BE MORE EFFECTIVE AND POSSIBLY SAFER THAN CURRENT… view more CREDIT: JULIA WAGNER Some of the most promising...
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Neutralizing antibodies isolated from COVID-19 patients may suppress virus
by Columbia University Irving Medical Center Cryo-EM reconstructions show how two different antibodies (blue) bind to the spike protein of the SARS-CoV-2 virus. Credit: David Ho / Columbia University Irving Medical Center Researchers at Columbia University Irving Medical Center have isolated antibodies from several COVID-19 patients that, to date, are among the most potent in...
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India clears a psoriasis drug for COVID-19, and a tiny US biotech’s shares soar
Dive Brief: India’s drug regulator has granted an emergency approval to the antibody drug itolizumab to treat the potentially deadly immune response, cytokine release syndrome, that appears to affect some patients hospitalized with acute respiratory distress related to COVID-19. The Drugs Controller General of India cleared the treatment for use after itolizumab, alongside standard of...