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Exploring genetic regulation of immunoglobulin A
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Exploring genetic regulation of immunoglobulin A

by Melissa Rohman, Northwestern University Genetic relationships between IgA levels and human disease traits. a genome-wide genetic correlation analyses between IgA levels and autoimmune, infectious, and cardio-metabolic traits after exclusion of the HLA region (*P < 0.05; two-sided unadjusted P-values for genetic correlation by LD score regression). Supplementary Table 12 provides genetic correlations with and without HLA with...

No immunoglobulin A leads to intestinal inflammation in mice
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No immunoglobulin A leads to intestinal inflammation in mice

by Tokyo Medical and Dental University  The small intestine is composed of duodenum, jejunum, and ileum (left). IgA deficiency causes distortion of the gut microbiota, especially in the ileum, and inflammatory cytokines are secreted from T cells, resulting in inflammation of the ileum (right). Credit: Tokyo Medical and Dental University While researchers have known for years that...