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Genetically Modified Pluripotent Stem Cells May Evade Immunological Rejection After Transplantation
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Genetically Modified Pluripotent Stem Cells May Evade Immunological Rejection After Transplantation

Researchers say the genetically engineered stem cells also could pave the way for new regenerative medicine treatments for diseases such as Type 1 diabetes. Deepta Bhattacharya, who is on the University of Arizona Health Sciences Center for Advanced Molecular and Immunological Therapies advisory council, is a professor of immunobiology in the UArizona College of Medicine...

Study shows genetically modified pluripotent stem cells may evade immunological rejection after transplantation
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Study shows genetically modified pluripotent stem cells may evade immunological rejection after transplantation

by University of Arizona Generation of an HLA-I/II and MICA/B-deficient hESC line (A) Representation of the Cas9 editing strategy. Wild-type H1 hESCs were transfected with a Cas9 construct and up to three gRNAs at a time. gRNAs were for β2M, TAP1, CD74, CIITA, MICA, and MICB. Individual colonies were picked and sequenced to identify ones with...