A better understanding of clinical outcomes, tumour dynamics and immune system interactions could lead to better outcomes. Produced by CAR-T-cell therapies have delivered transformative benefits for many cancer patients, but some recipients respond better than others.Credit: Thom Leach/Science Photo Library/Getty Crystal Mackall has seen the transformative impact of cellular therapies in paediatric oncology. She was...
Tag: <span>immunotherapies</span>
Post
New immunotherapy shows complete responses in mantle cell lymphoma
Patients with a rare blood cancer that has relapsed or become resistant to treatment have shown a high response rate to a potent new immunotherapy drug, in a Peter Mac-led clinical trial. The early-phase NP30179 trial involved 60 patients who were treated with glofitamab, a drug which harnesses the patient’s immune system to fight their cancer....
Post
Progress in developing specific immunotherapies for type 1 diabetes
GERMANS TRIAS I PUJOL RESEARCH INSTITUTE IMAGE: IGTP AND AHEAD THERAPEUTICS TEAM view moreCREDIT: IGTP Researchers from Germans Trias i Pujol Research Institute (IGTP) and Ahead Therapeutics SL have been exploring a treatment based on liposome-type nanoparticles to address the autoimmunity of type 1 diabetes for years. A study recently published in the Journal of...
Post
New clinical practice guideline provides evidence-based recommendations for immunotherapy for inhalant allergy
by American Academy of Otolaryngology — Head and Neck Surgery Credit: CC0 Public DomainThe American Academy of Otolaryngology–Head and Neck Surgery Foundation has published the Clinical Practice Guideline: Immunotherapy for Inhalant Allergy in Otolaryngology–Head and Neck Surgery. This clinical practice guideline identifies quality improvement opportunities and provides clinicians trustworthy, evidence-based recommendations on the management of...
Post
Drug mechanism opens door for new anti-cancer immunotherapies
by King’s College London Credit: CC0 Public DomainResearchers have revealed a new mechanism of targeted drug treatment used against chronic lymphocytic leukemia, through the promotion of immune cell function, that could be exploited using new anti-cancer immunotherapies. New research has revealed how a class of new medicines used to treat the blood cancer chronic lymphocytic leukemia...
Post
Customizing T cell-based immunotherapies using new ‘SNAPtag’ technology
by University of Pittsburgh Universal adaptor SNAP-CAR and SNAP-synNotch receptor function. a A benzylguanine motif (BG) is chemically conjugated to an antibody using a benzylguanine NHS ester. The BG-antibody conjugate then covalently binds to the extracellular SNAPtag enzyme through a self-labeling reaction. b SNAPtag receptors enable the targeting of multiple different antigens using the same receptor...
Post
Cell type key to successful immunotherapies for chronic viral infections identified
by Universitat Pompeu Fabra – Barcelona Diagram of the finding. Credit: Cell Reports (2023). DOI: 10.1016/j.celrep.2023.112123 An international study led by researchers from the Infection Biology Laboratory at the UPF Department of Medicine and Life Sciences (MELIS) establishes that one type of dendritic cell is crucial for the success of immunotherapeutic treatments to control chronic viral infections. These dendritic...
Post
Bioengineered synthetic gene circuits enhance cancer immunotherapies
AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE (AAAS) In two separate studies, researchers demonstrate how synthetic biology can be used to tackle a difficult issue in cancer immunotherapy: the way immunotherapy-related approaches focused on short-term killing of tumor cells may fail to eradicate tumors because growth of tumors happens on longer timescales. Here, two research groups...
Post
Biomarker predicts resistance to immunotherapies in melanoma
by Duke University Medical Center Schematic of the tumor-intrinsic NLRP3-HSP70 signaling axis and its role in supporting metastatic progression in the lung in response to anti-PD-1 immunotherapy. Credit: B. Theivanthiran, et al., Science Translational Medicine (2022) Duke Cancer Institute researchers have identified potential biomarkers that predict the likelihood for checkpoint inhibitor drugs to backfire, driving hyper-progression of melanoma...
Post
New avenues for the optimisation of dendritic cell-based cancer immunotherapies
by University of Helsinki Artistic rendering of the surface of a human dendritic cell illustrating sheet-like processes that fold back onto the membrane surface. Credit: National Institutes of Health (NIH) A recent study from the University of Helsinki reveals that inhibiting certain adhesion receptors on the surface of dendritic cells, the main antigen-presenting cells of the...