by Doherty Institute for Infection and Immunity Credit: CC0 Public Domain In a significant step forward in understanding the crucial role tissue-resident memory T (TRM) cells play in the immune system, researchers have for the first time described how the cells behave in different tissues around the body. This discovery adds to the growing knowledge base around...
by La Jolla Institute for Immunology Anti-PD-1 cancer immunotherapies boost the body’s cancer-fighting T cells, but in many patients, suppressive Tfr cells bring that progress to a grinding halt. Credit: La Jolla Institute for Immunology New research led by scientists at La Jolla Institute for Immunology (LJI) and the University of Liverpool may explain why many cancer patients...
UNIVERSITY OF KONSTANZ A new cancer vaccine could boost the positive effects of existing immunotherapy drugs, improving the success rate of treatments from 20% to 75% of cases, according to a new study by immunologists from the University of Konstanz. The vaccine, which incorporates a new immunostimulant that is safe for use in humans, was...
by Vanderbilt University Medical Center Yu Shyr, PhD, the Harold L. Moses Chair in Cancer Research and chair of the Department of Biostatistics at Vanderbilt University Medical Center Credit: Vanderbilt University Medical Center Immune checkpoint inhibitors have transformed cancer care to the point where the popular Cox proportional-hazards model provides misleading estimates of the treatment effect,...
UNIVERSITY OF CALIFORNIA – IRVINE IMAGE: REGULATORY T CELLS (GREEN) SHOWN INTERACTING WITH PATHOGENIC TH17 CELLS (RED) NEAR COLLAGEN FIBERS (BLUE) IN THE SPINAL CORD IN A MODEL OF MULTIPLE SCLEROSIS. Irvine, CA – September 21, 2020 – In a new University of California, Irvine-led study, researchers have discovered how regulatory T cells (Treg) are instrumental in...
WALTER AND ELIZA HALL INSTITUTE AUSTRALIAN RESEARCHERS HAVE IDENTIFIED ‘NATURAL KILLER’ CELLS AS AN IMPORTANT COMPONENT OF ANTI-TUMOUR IMMUNITY TO LUNG CANCER. IMAGE: SECTIONS OF LUNG CONTAINING TUMOURS, BY DR KAREN DOGGETT Immune cells called ‘natural killer’ (NK) cells could be a powerful weapon for fighting lung cancer, according to Australian researchers. Studying preclinical and...
Two experimental drugs fight non-small cell lung cancer by affecting their blood vessels, oxygen levels, and other environmental factors UT SOUTHWESTERN MEDICAL CENTER FROM LEFT: DRS. RALPH MASON, LI LIU, AND YIHANG GUO, AND RESEARCHER JENI GERBERICH USED A NEW TOOL CALLED MULTISPECTRAL OPTOACOUSTIC TOMOGRAPHY TO EXAMINE NON-SMALL CELL LUNG CANCER TUMORS GROWING. DALLAS –...
by University of Helsinki Activating the immune system is a promising form of cancer treatment. Researchers at the University of Helsinki and Helsinki University Hospital as well as the University of Eastern Finland mapped out the immune landscape of hematological malignancies in a dataset covering more than 10,000 patients to identify drug targets and patient...
Natural killer immune cells engineered to target the PD-L1 molecule can directly kill tumour cells in mice and reduce the numbers of immunosuppressive cells harbouring PD-L1 in mice and humans Scientists have engineered natural killer immune cells that not only kill head and neck tumour cells in mice but also reduce the immune-suppressing myeloid cells...
by University of Cincinnati UC researchers have found a potential new combination therapy for breast cancer that would integrate use of the body’s immune system with targeted treatment for a particular protein that advances cancer. The study, published in the journal Cancer Research, a journal of the American Association for Cancer Research, provides data that...
