Vienna, Austria, June 18, 2020 – AFFiRiS AG, a clinical-stage biotechnology company developing novel disease-modifying specific active immunotherapies (SAITs), today announced that detailed results of the phase 1 clinical program with its lead candidate PD01 in early Parkinson’s disease (PD) patients were published in the peer-reviewed journal The Lancet Neurology. The results of the long-term...
Tag: <span>immunotherapies</span>
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Birmingham scientists ‘re-train’ immune system to prevent attack of healthy cells
The body’s immune system can be re-wired to prevent it from recognising its own proteins which, when attacked by the body, can cause autoimmune diseases like multiple sclerosis, a significant new study by UK scientists has found. Autoimmune diseases are caused when the immune system loses its normal focus on fighting infections or disease within...
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Primary care experts produce guidance for limiting the psychological impacts of coronavirus
by St. George’s University of London New guidance published in the BMJ today during Mental Health Awareness Week has outlined guidance for primary care workers on the best-evidenced methods to mitigate the psychological effects of social distancing. Recommended interventions include remote consultations and social prescribing, such as online exercise and dance classes. The new guidance,...
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T-cells could be made into better cancer killers by increasing their protein production
Hollings Cancer Center researchers at the Medical University of South Carolina have developed a technique to monitor protein production in a type of immune cell known as a T cell & have shown that T cells with robust protein production are more effective MEDICAL UNIVERSITY OF SOUTH CAROLINA A team of scientists from Hollings Cancer...
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Mucus breakthrough could help patients breathe easy
A discovery about how mucus thickness is regulated could help to improve airway-clearing treatment options for people with chronic respiratory conditions such as asthma, cystic fibrosis and chronic obstructive pulmonary disease (COPD) At a glance Researchers have discovered the reason why the excessive amounts of mucus produced by patients with respiratory illnesses is thicker than...
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Interleukin-12 electroporation may sensitize ‘cold’ melanomas to immunotherapies
by American Association for Cancer Research Combining intratumoral electroporation of interleukin-12 (IL-12) DNA (tavokinogene telseplasmid, or TAVO) with the immune checkpoint inhibitor pembrolizumab (Keytruda) led to clinical responses in patients with immunologically quiescent advanced melanoma, according to results from a phase II trial published in Clinical Cancer Research, a journal of the American Association for...
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Scientists uncover a mechanism that could lead to new immunotherapies head and neck cancer
by Katie Pence, University of Cincinnati Researchers at UC have discovered a previously unknown mechanism that could explain the reason behind decreased immune function in cancer patients and could be a new therapeutic target for immunotherapy for those with head and neck cancers. The authors share these findings in an article published in the journal...
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Early immune response may improve cancer immunotherapies
by Natasha Wadlington, University of Illinois at Chicago In a paper published in the Journal of Biological Chemistry, University of Illinois at Chicago researchers and colleagues report a new mechanism for detecting foreign material during early immune responses. Viruses, bacteria and cancer have many ways to replicate and survive in our bodies. For viruses and...
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Machine Learning Helps Design Complex Immunotherapies
Researchers from Northwestern University have leveraged machine learning to aid in the design of nano-medicines for immunotherapy. They utilized a high-throughput method to synthesize 800 unique immunostimulatory nanoparticles called Spherical Nucleic Acids (SNAs). “Spherical nucleic acids represent an exciting new class of medicines that are already in five human clinical trials for treating diseases, including...
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Patients on immunotherapies should consume more fiber, fewer probiotics
By Liji Thomas, MD Reviewed by Kate Anderton, B.Sc. A new study has found that taking probiotics could drastically reduce the response of cancer patients to immunotherapy. Probiotics are freely available without prescription and are not regulated by the US Food and Drug Administration. On the other hand, patients on a fiber-rich diet showed a five-fold increase in response. The study was presented on April 2,...