Lung CA seen on CXR. Immunotherapy, which has achieved remarkable results in late-stage lung cancer patients, can also hold great hope for newly diagnosed patients, cutting the deadly disease off before it has the chance to take hold and offering a potential cure, according to a new Mount Sinai study published today in Cell. Researchers...
Tag: <span>Immunotherapy</span>
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Atlases of immune cells surrounding tumors may guide immunotherapy
Fluorescent imaging of a tumor section identifies different types of macrophages (green) and T cells (blue) present in the microenvironment of renal cell carcinoma. Two independent studies have begun mapping the connections between and identities of the thousands of immune cells surrounding human tumors. One research group, looking at kidney cancer, found that tumors...
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Engineering cells to make immunotherapy more effective
Microscopy image of cells within nanowell array chips. Immunotherapy, in which cells from the human immune system are unleashed to fight disease, has been the big story in cancer treatment over the past few years. When it works, it can spur long-lasting remission in patients for whom other treatments have failed. But most patients...
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First patient receives experimental immunotherapy for cancer
The experimental MG1MA3 virus used in this trial is derived from a virus called Maraba that was first isolated from Brazilian sandflies. It has been engineered to infect and kill cancer cells directly, while also triggering an immune …more A Hamilton patient is the first trial participant to receive a novel experimental immunotherapy treatment for...
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Research team discovers how immunotherapy can fight some cancers
What if our immune system could cure cancer? This logic seems almost too simple to be true, but it forms the basis of an emerging cancer treatment—immunotherapy. André Veillette, a researcher at the Institut de recherches cliniques de Montréal (IRCM) / Montreal Clinical Research Institute and a professor of Université de Montréal’s Faculty of Medicine,...
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Annual flu jab may pose greater risk for lung cancer patients under immunotherapy
Lung cancer patients treated with PD-1/PD-L1 checkpoint inhibitors may be at increased risk of adverse events after receiving the seasonal influenza vaccination, according to the first study measuring this effect. The results, presented today at the European Lung Cancer Conference (ELCC) 2017 in Geneva, Switzerland, offer the first hint of a possible contraindication with two...
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Nanoparticle vaccine shows potential as immunotherapy to fight multiple cancer types
Laser light can be seen scattered by nanoparticles in a solution of the UTSW-developed nanovaccine. Researchers from UT Southwestern Medical Center have developed a first-of-its-kind nanoparticle vaccine immunotherapy that targets several different cancer types. The nanovaccine consists of tumor antigens — tumor proteins that can be recognized by the immune system — inside a synthetic...
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Th17 cells could facilitate wider clinical use of adoptive immunotherapy
CD8+ T cells and Th1 cells become exhausted and lose antitumor efficacy as they’re expanded for adoptive cell therapy. Th17 cells are resistant to degradation (senescence) and retain their antitumor efficacy, resulting in large numbers of …more Medical University of South Carolina (MUSC) investigators report that long-term expansion protocols for adoptive cancer immunotherapy do not...
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Are tumor cells Glutamine addicts?
Most cancers require large amounts of glutamine for rapid growth and there are numerous studies indicating that they cannot survive without it, a phenomenon termed ad “glutamine addiction”. This led to the idea that preventing tumors from glutamine uptake could be a potential therapeutic strategy. Researchers from Berlin and Wurzburg, Germany conclude that glutamine deprivation...
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Specialized blood vessels enhance tumor-fighting Immunotherapy
Researchers from VIB and KU Leuven, together with colleagues from the University of California and the Swiss Institute for Experimental Cancer Research have demonstrated that, anti-angiogenic therapy can improve immune boosting treatments. The combination of these two therapies result in the growth of specialized vessels that deliver cancer-fighting immune cells to the tumor, potentially leading...