WYSS INSTITUTE FOR BIOLOGICALLY INSPIRED ENGINEERING AT HARVARD IMAGE: THE RESEARCHERS VISUALIZED THE CELL-PERMEABLE POROUS STRUCTURE OF AN INJECTABLE SIVET IMMUNO-MATERIAL USING SCANNING ELECTRON MICROSCOPY ANALYSIS (SEM). CREDIT: WYSS INSTITUTE AT HARVARD UNIVERSITY By Benjamin Boettner (BOSTON) — Cancer immunotherapy has brought major improvement in patient survival and quality of life, especially with the success...
UNIVERSITY OF COLORADO ANSCHUTZ MEDICAL CAMPUS A new study published in the Journal of the National Cancer Institute brings researchers and oncologists one step closer to better understanding the complexities of PD-1 inhibitors, a common type of immunotherapy, and their intracellular signaling on cancer behavior. Until recently, cancer intrinsic PD-L1 signaling has been only partially reported in...
The Desai Lab shows how clinical use of some monoclonal antibodies may cause life-threatening systemic fungal infections HACKENSACK MERIDIAN HEALTH IMAGE: DR. JIGARKUMAR DESAI, OF THE HACKENSACK MERIDIAN CDI Major fungal infections have become more common across the globe, and one unexpected phenomenon among the rise of fungi is life-threatening infections as a result of...
INSTITUT PASTEUR VIDEO: CAR T CELLS ATTACKING A TUMOR, VISUALIZED USING INTRAVITAL IMAGING. LIVE TUMOR CELLS ARE SHOWN IN WHITE, APOPTOTIC TUMOR CELLS IN BLUE AND CAR T CELLS IN GREEN. The aim of immunotherapy strategies is to use cells in the patient’s own immune system to destroy tumor cells. CAR T cell therapy is...
by Perelman School of Medicine at the University of Pennsylvania Credit: Pixabay/CC0 Public Domain Over the past decade, the approval of immune checkpoint inhibitors has revolutionized treatment for patients with advanced lung cancer, helping many live longer lives and improving overall survival for the disease. However, an important question has remained unanswered: How long should a...
by Hackensack Meridian Health Graphical abstract. Credit: Cell (2023). DOI: 10.1016/j.cell.2023.04.031 Major fungal infections have become more common across the globe, and one unexpected phenomenon among the rise of fungi is life-threatening infections as a result of a complication of certain immunotherapies and small molecule kinase inhibitors. A scientist at the Hackensack Meridian Center for Discovery and...
by Thamarasee Jeewandara , Medical Xpress Design of IL2-ep13nsEV and its utilization in treating breast cancer. To generate this active immunotherapy, the sEVs from autologous DCs are engineered with surface membrane–bound IL2 by expressing IL2-MFG-E8. This personalization of DC-derived sEV (p13nsEV) is achieved by loading lysed surgically harvested breast cancer cells onto engineered autologous DCs...
by King’s College London CSPG4 expression in malignant melanoma and normal tissues. a CSPG4 mRNA expression, derived from RNAseq data, across cell lines of different cancer cell types. n represents the number of cell lines (data from Cancer Cell Line Encyclopedia (CCLE), portals.broadinstitute.org/ccle, n = 56, n = 59, n = 26, n = 57, n = 28, n = 27, n = 48, n = 127, n = 41, n = 32, n = 26, n = 37, n = 8, n = 50, and n = 58, respectively) (p = 0.0156 and p ≤ 0.0001). b CSPG4 gene expression in tissues across cancer types (data and images from Human Protein...
by Ohio State University Medical Center Melanoma in skin biopsy with H&E stain—this case may represent superficial spreading melanoma. Credit: Wikipedia/CC BY-SA 3.0 Data from a national clinical trial shows that a striking 89% of patients with desmoplastic melanoma responded to immunotherapy (pembrolizumab) alone, suggesting that many patients could avoid the risk for toxicity from combination...
by Johns Hopkins University School of Medicine Pathologists look through a microscope to evaluate H&E slides for tumor infiltrating immune cells and necrosis in patients with kidney cancer who go on to receive immunotherapy. Credit: Julie Stein Deutsch via Biorender The number of immune cells in and around kidney tumors, the amount of dead cancer...
