by Dana-Farber Cancer Institute Credit: Unsplash/CC0 Public Domain Immunotherapies, such as anti-PD-1 and anti-PD-L1, have become standard first line therapies for patients with advanced renal cell carcinoma (kidney cancer). Most patients, however, eventually experience disease progression, with no consensus on what therapy to use next. In an open-label phase 2 study, led by Dana-Farber Cancer...
Tag: <span>Immunotherapy</span>
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Two cancer research studies reveal essential role of neutrophils in immunotherapy
by Ludwig Institute for Cancer Research Graphical abstract. Credit: Daniel Hirschhorn et al, T cell immunotherapies engage neutrophils to eliminate tumor antigen escape variants, Cell (2023). DOI: 10.1016/j.cell.2023.03.007 Two independent Ludwig Cancer Research studies published in the current issue of the journal Cell show that immune cells known as neutrophils, whose abundance in the microenvironment of tumors has traditionally...
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Synthetic protein tweak could lead to universal cancer immunotherapy
By Michael Irving March 19, 2023 A new technique could pave the way for off-the-shelf immunotherapies for cancer Depositphotos Scientists at ETH Zurich have made a breakthrough towards designing an off-the-shelf treatment for immunotherapy against cancer. A synthetic protein tweak can allow immune cells from any donor to be given to any patient without the risk of...
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New immunotherapy holds promise for ovarian cancer
by Karolinska Institutet Intermediate magnification micrograph of a low malignant potential (LMP) mucinous ovarian tumour. H&E stain. The micrograph shows: Simple mucinous epithelium (right) and mucinous epithelium that pseudo-stratifies (left – diagnostic of a LMP tumour). Epithelium in a frond-like architecture is seen at the top of image. Credit: Nephron /Wikipedia. CC BY-SA 3.0 CAR...
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Why lung cancer doesn’t respond well to immunotherapy
Anne Trafton | MIT News Office Publication Date: February 2, 2023 PRESS INQUIRIES Caption: A new MIT study explains why dendritic cells (green) in lymph nodes that drain from the lungs fail to stimulate killer T cells (white) to attack lung tumors.Credits: Courtesy of the researchers Immunotherapy — drug treatment that stimulates the immune system...
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Drug combo breaks down cancer resistance to immunotherapy
by Ecole Polytechnique Federale de Lausanne A schematic summary of the study. Credit: Douglas Hanahan (EPFL) Immunotherapy is a way of treating cancer by reprogramming the patient’s immune system to attack their tumor. This cutting-edge approach has significantly impacted the treatment of cancer patients, and already boasts cases of long-term remission. Nonetheless, many patients either...
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Using synthetic gene circuits to better control the timing of immunotherapy
Reviewed by Emily Henderson, B.Sc. Dec 16 2022 In two separate studies, researchers demonstrate how synthetic biology can be used to tackle a difficult issue in cancer immunotherapy: the way immunotherapy-related approaches focused on short-term killing of tumor cells may fail to eradicate tumors because growth of tumors happens on longer timescales. Here, two research...
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Immunotherapy eliminates disease-causing cells in mice with MS-like disease
by Washington University School of Medicine Credit: Pixabay/CC0 Public Domain The cancer therapy known as CAR-T has revolutionized treatment of some blood cancers since it was introduced in 2017. The therapy uses genetically altered immune cells to home in on cancer cells and destroy them. Now, studying mice with an autoimmune disease similar to multiple...
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‘CAR pooling’ screens identify most effective cancer immunotherapy cells
by University of California, San Francisco Generation and screening of a pooled library of CARs with diverse signaling domains. (A) Our CARs combine an αCD19 ScFv (FMC63), a CD8 hinge and transmembrane domain (TMD), an intracellular signaling domain, and a CD3ζ domain (left). Forty domains from across the human proteome were codon-optimized, synthesized, pooled into...
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Hormone therapy could lower risk of immunotherapy-associated myocarditis in women
by University of Texas M. D. Anderson Cancer Center Stained images of heart tissues in female and male mice with melanoma, treated with IgG antibodies or immune checkpoint inhibitors (ICI). Credit: Y. Zhang, et al., Science Translational Medicine (2022) A new preclinical study from researchers at The University of Texas MD Anderson Cancer Center and the University...