by Children’s Hospital of Philadelphia GPC2 is expressed in pediatric brain tumors. (A) GPC2 RNA sequencing data across OpenPBTA pediatric brain tumors cohorts. Neuroblastoma GPC2 RNA sequencing included for comparison on the left. (B) Using a cut-off value of 10 TPM, percentage of tumors in the OpenPBTA dataset with high expression of GPC2. (C) RNA...
by University of Rhode Island Credit: Unsplash/CC0 Public Domain Researchers from the University of Rhode Island and Yale University have demonstrated a promising new approach to delivering immunotherapy agents to fight cancer. The approach involves tethering an immunotherapy agent called a STING agonist to an acid-seeking molecule called pHLIP (pH-low insertion peptide). The pHLIP molecules...
by Monash University Credit: Pixabay/CC0 Public Domain Researchers have discovered that some immunotherapy treatments used to treat cancer can cause fertility damage. It means these treatments could affect the future fertility and hormonal health of female cancer survivors, prompting experts to call for more research and preventative measures, such as freezing eggs. Led by the Biomedicine...
by University of Pittsburgh An artist’s depiction of a T cell. Credit: NIAID During a battle with cancer, T cells can become exhausted and are no longer able to function properly. The early phase of exhaustion can sometimes be reversed with immunotherapy drugs, but once T cells become too exhausted, it had been thought that this...
by Will Doss, Northwestern University Graphical abstract. Credit: Journal of Clinical Investigation (2022). DOI: 10.1172/JCI158800 An epigenetic inhibitor can boost immune system activity in patients with ovarian cancer, making them more suitable for treatment with immunotherapy, according to a Northwestern Medicine study published in the Journal of Clinical Investigation. This could be one strategy to aid immunotherapy in...
by New York University The steps of CIRCLE: 1) Combine immunotherapy whole-exome sequencing datasets. 2) Identify mutated genes and pathways. 3) Test candidate genes and pathways for response association. 4) Predictive framework for therapy response (determining Responder or Non-responder). Credit: Sanjana and Imieliński Labs Immunotherapies, such as immune checkpoint inhibitors, have transformed the treatment of advanced...
by Pai Liu, Michigan State University Graphical abstract. Credit: Molecular Therapy – Oncolytics (2021). DOI: 10.1016/j.omto.2021.12.004 Advancements in cancer research and treatment have resulted in great improvements in survival rates—today, there are almost 17 million people in the United States alone who have survived their diagnosis because of the physicians and scientists who have dedicated their careers to...
UNIVERSITY OF MISSOURI-COLUMBIA IMAGE: CO-PRINCIPAL INVESTIGATOR GUANGFU LI, PHD, DVM, ASSOCIATE PROFESSOR IN THE DEPARTMENT OF SURGERY AND DEPARTMENT OF MOLECULAR MICROBIOLOGY AND IMMUNOLOGY AT THE UNIVERSITY OF MISSOURI SCHOOL OF MEDICINE. CREDIT: JUSTIN KELLEY/UNIVERSITY OF MISSOURI HEALTH CARE Researchers from the University of Missouri School of Medicine have discovered a specific combination immunotherapy that shows promise...
OCHSNER HEALTH SYSTEM IMAGE: DANIEL JOHNSON, MD, IS A LEAD AUTHOR ON A CANCER CELL STUDY SHOWING THAT BLOCKING THE EXPRESSION OF IL-6 COULD DE-COUPLE AUTOIMMUNITY FROM ANTITUMOR IMMUNITY. CREDIT: OCHSNER HEALTH Immune checkpoint inhibitors have revolutionized the treatment of many cancers by using our body’s immune system to kill cancer. These treatments sometimes can...
UNIVERSITY OF TEXAS M. D. ANDERSON CANCER CENTER HOUSTON ― Researchers at The University of Texas MD Anderson Cancer Center have identified a novel strategy to reduce immune-related adverse events from immunotherapy treatment by targeting the cytokine interleukin-6 (IL-6). The study, published today in Cancer Cell, establishes a proof of concept for combining immune checkpoint blockade with cytokine blockers to selectively...
