Pluripotent stem cells may acquire genetic and epigenetic variants during culture following their derivation. At a conference organized by the International Stem Cell Initiative, and held at The Jackson Laboratory, Bar Harbor, Maine, October 2016, participants discussed how the appearance of such variants can be monitored and minimized and, crucially, how their significance for the...
Tag: <span>induced pluripotent stem cells (iPSCs)</span>
Post
New method that leads to the formation of specialized tissue cells for disease treatment
A new method that leads to the formation of specialized tissue cells could improve the understanding of neurodegenerative diseases, inflammatory diseases and cancer. Macrophages are specialized cells involved in tissue development, repair and immunity. Macrophage communities in several types of tissues are derived from ‘yolk-sac precursor cells’, named primitive macrophages, planted there during early embryonic development....
Post
Immune cell therapy on liver cancer using interferon beta produced with stem cells
(A) Bio-imaging analysis to evaluate the therapeutic effect of iPS-ML producing IFN-β on metastatic liver cancer. (B) Quantification of the image data shown in A. (C) Histological data indicating migration of iPS-ML (PKH26, red) into …more Causes of the most common form of liver cancer, hepatocellular carcinoma (HCC), include hepatitis B or C, cirrhosis, obesity,...
Post
Researchers identify a new way to promote tissue regeneration
Cell (stock image). The use of iPSCs to generate tissues would revolutionize transplantation, facilitating the growth of artificial organs, say authors. Houston Methodist researchers have identified an immune pathway that promotes the formation of a cell that can develop into new tissues and organs. In a new study published in the journal Stem Cells, a team...