by Sarah C.P. Williams, Columbia University Irving Medical Center Keeping neuroinflammation in check. Normal neurons (top panel) produce a small amount of double-stranded DNA (green) that keeps inflammation at a low level and ready to fight incoming viruses. But if neurons accumulate extremely high levels of dsRNA, as seen in ADAR1 knockout neurons (lower panel),...
Researchers at Trinity College Dublin have uncovered a new metabolic process involved in the immune system’s inflammatory processes. The discovery suggests manipulating this mechanism could essentially “switch off” inflammation, which the researchers hope could lead to the development of entirely new anti-inflammatory drugs to treat a host of auto-immune disorders. When the body is working...
