by Josh Barney, University of Virginia Age-related changes in whole-blood gene expression are associated with increased inflammatory gene transcription and decreased expression of genes encoding mitochondrial Ca2+ transport. Credit: Nature Aging (2023). DOI: 10.1038/s43587-023-00436-8 University of Virginia School of Medicine researchers have discovered a key driver of chronic inflammation that accelerates aging, a finding that could lead to longer, healthier...
UNIVERSITY OF CALIFORNIA – SAN DIEGO IMAGE: VETERANS WITH GULF WAR ILLNESS HAVE LONG STRUGGLED TO GET A PROPER DIAGNOSIS AND TREATMENT, DESPITE EXPERIENCING SYMPTOMS FOR SEVERAL DECADES. CREDIT: PHOTO BY JAKOB OWENS ON UNSPLASH Gulf War Illness (GWI) is a chronic multisymptom health condition affecting one-third of all veterans who served in the 1991...
by Association of Basic Medical Sciences of FBIH Molecular mechanism of miR-212-3p in AD-induced neuroinflammation. Credit: Bosnian Journal of Basic Medical Sciences Alzheimer’s disease (AD) is a progressive neurological disorder that causes the brain to shrink (atrophy) and brain cells to die. AD is the most common cause of dementia—a continuous decline in thinking, behavioral, and...
by Nagoya University Pure capped mRNA vaccine opens the door to more effective vaccines with lower chances of inflammation. Credit: Mizuki Tada A research group from Japan has developed a method to produce highly active mRNA vaccines at high purity using a unique cap to easily separate the desired capped mRNA. This “Purecap” technique extracted up to 100%...
YORK UNIVERSITY TORONTO, CANADA, June 15, 2023 – Researchers have long known that moderate exercise has a beneficial impact on the body’s response to inflammation, but what’s been less understood is why. New research coming out of York University done on a mouse model suggests that the answers may lie at the production level of macrophages — white blood cells responsible for killing off...
by NYU Langone Health Atherosclerosis is a condition affecting the cardiovascular system. If atherosclerosis occurs in the coronary arteries (which supply the heart) the result may be angina pectoris, or in worse cases a heart attack. Credit: Wikipedia/CC BY 3.0 An experimental drug already tested as a potential treatment for cancer, lung, and Alzheimer’s disease may...
MAY 30TH, 2023 CONN HASTINGS GI, MATERIALS, MEDICINE, SURGERY Researchers at MIT have developed smart sutures with a hydrogel coating that contains sensing and drug delivery components, and could even be used to implant therapeutic cells. The sutures are made using pig tissues that have been decellularized with detergents to reduce the possibility that they could provoke...
by Massachusetts Institute of Technology Credit: Pixabay/CC0 Public Domain Inspired by sutures developed thousands of years ago, MIT engineers have designed “smart” sutures that can not only hold tissue in place, but also detect inflammation and release drugs. The new sutures are derived from animal tissue, similar to the “catgut” sutures first used by the ancient Romans....
by CNRS CD44 mediates copper uptake. a, Experimental setup used to generate inflammatory monocyte-derived macrophages (MDMs). b, Flow cytometry of CD44 in MDMs. Data are representative of n = 13 donors. AU, arbitrary units. c, ICP-MS of cellular copper in MDMs (n = 9 donors). d, ICP-MS of cellular copper in aMDMs with short interfering RNA (siRNA) knockdown of indicated receptors and transporters (n = 6 donors)....
by Garvan Institute of Medical Research Paradoxically, a gene variant that increases inflammation also has a protective effect on the kidneys. Seen here, kidney cell nuclei (blue) and an influx of immune regulatory cells (pink) that prevent damage in an injured kidney. Credit: Garvan A discovery about gene variants of an inflammation ‘brake’ brings scientists a step...
