Lucy Hicks A new diagnostic tool can effectively discriminate different rheumatologic conditions and could potentially aid in the diagnosis of early inflammatory arthritis. The algorithm — called Genetic Probability tool (G-PROB) — uses genetic information to calculate the probability of certain diseases. “At such an early stage of disease, it’s not always easy to determine...
Tag: <span>inflammatory arthritis</span>
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New PET tracer detects inflammatory arthritis before symptoms appear
by Society of Nuclear Medicine and Molecular Imaging A) PET images of [68Ga]Ga-DOTA-ZCAM241 uptake at baseline and 3, 7, and 12 days after injection as inflammatory arthritis developed in single representative individual mouse. Images are normalized to SUV of 0.5 for direct comparison between time points. (B) CD69 immunofluorescence Sytox (Thermo Fisher Scientific) staining of...
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Unique immune response found in patients who experience inflammatory arthritis as side effect of cancer therapies
by Brigham and Women’s Hospital Multiplexed immunofluorescence of synovial tissue. Multiplexed immunofluorescence images showing an example of a Ki67+PD-1+ synovial CD8 T cell (white arrow). CD3 staining is shown in red, CD8 in yellow, nuclear stain DAPI in blue, Ki67 in green and PD-1 in cyan. Credit: Science Immunology (2023). DOI: 10.1126/sciimmunol.add1591 Immune checkpoint inhibitor (ICI) therapies used to...
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Ankylosing spondylitis: Machine learning could pave the way for early diagnosis of inflammatory arthritis
by Jonathan Kennedy, The Conversation An X-ray image comparing a healthy spine and one showing signs of ankylosing spondylitis. Credit: Suttha Burawonk/Shutterstock Ankylosing spondylitis (AS) is the second most common type of inflammatory arthritis, often affecting teenagers and young adults. Symptoms of AS can include back pain, stiffness, joint inflammation (arthritis), inflammation where tendons attach to bones...
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People with alopecia found to have higher risk for inflammatory arthritis
by Lori Solomon Alopecia areata (AA) is associated with a higher risk for inflammatory arthritis, according to a study published online April 28 in the Journal of the American Academy of Dermatology. Colin M. Kincaid, from University of California at Irvine, and colleagues used medical records from 75 health care organizations (TriNetx) to determine if an association exists between...
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Memories… or why inflammatory arthritis always recurs in certain joints
BOSTON CHILDREN’S HOSPITAL When joints flare up in people with rheumatoid arthritis and related diseases, the joints involved are often the same as those affected before. For example, if arthritis started in the right knee, it is much more likely to flare there than in the left knee, even if the arthritis had been in...
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Recognizing young people’s perspectives in inflammatory arthritis
by EULAR Figure 1 Example outlining the different steps of the analysis from a meaning unit to lower and higher-level concepts. PROMs, patient-reported outcome measures. Inflammatory arthritis is the name of a group of diseases that cause joint pain and swelling. This happens because the body’s immune system attacks its own tissues and causes inflammation....
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Tracking movement of immune cells identifies key first steps in inflammatory arthritis
Identification of molecule required for immune cells to enter joint could lead to new treatment approaches In the image on the left, many green-labeled neutrophils carrying the C5a receptor have moved out from the grey blood vessel into the joint of a mouse in which inflammatory arthritis has been induced. In an animal lacking expression...