The study, published in EMBO Molecular Medicine, shows that blockade of the protease MT1-MMP protects the vasculature in the inflamed gut CENTRO NACIONAL DE INVESTIGACIONES CARDIOVASCULARES CARLOS III (F.S.P.) Scientists at the Centro Nacional de Investigaciones Cardiovasculares (CNIC) and the Centro de Investigaciones Biológicas (CIB) of the Consejo Superior de Investigaciones Científicas (CSIC) have identified...
Tag: <span>inflammatory bowel disease (IBD)</span>
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New insights into how immune system and inflammation play a role in PD
Reviewed by Kate Anderton, B.Sc. (Editor) Relatively new research findings indicating that the earliest stages of Parkinson’s disease (PD) may occur in the gut have been gaining traction in recent years. In a review published in the Journal of Parkinson’s Disease, Tomasz Brudek, PhD, evaluates evidence for the association between inflammatory bowel disease (IBD) and...
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Scientists uncover the process behind protein mutations that impact gut health
Study examines why a protein mutation that causes inflammatory bowel diseases is dysfunctional ST. MICHAEL’S HOSPITAL A new study led by researchers at St. Michael’s Hospital and the Princess Margaret Cancer Centre in Canada and Zhejiang University School of Medicine in China has uncovered why a protein mutation that causes inflammatory bowel diseases is dysfunctional. Published today...
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New method divides patients with ulcerative colitis in groups
by Karolinska Institutet Researchers at Karolinska Institutet in Sweden have found a way of using gene expression conserved across species to divide patients with the inflammatory bowel disease ulcerative colitis into two distinct groups. The findings are published in the journal Nature Communications, and the researchers hope that the method can also be used to subdivide other autoimmune diseases. Ulcerative colitis is an inflammatory bowel...
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Medication linked to increased risk of inflammatory bowel disease
WILEY Medications that target tumor necrosis factor alpha (TNFα), a protein involved in inflammation, have revolutionized the management of certain autoimmune diseases, but paradoxically, these agents might provoke the development of other autoimmune conditions. In an Alimentary Pharmacology & Therapeutics study of 17,018 individuals with autoimmune diseases who were treated with anti-TNFα medications–mostly infliximab, etanercept, and adalimumab–and...
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Cannabidiol is a powerful new antibiotic
by American Society for Microbiology New research has found that Cannnabidiol is active against Gram-positive bacteria, including those responsible for many serious infections (such as Staphyloccocus aureus and Streptococcus pneumoniae), with potency similar to that of established antibiotics such as vancomycin or daptomycin. The research is presented at ASM Microbe, the annual meeting of the American Society for Microbiology....
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Metabolite from pomegranate diet reduces inflammatory bowel diseases
inStem and University of Louisville research teams identify Urolithin A and its synthetic analog to improve gut barrier and reduce inflammation NATIONAL CENTRE FOR BIOLOGICAL SCIENCES Bangalore, INDIA – Millions of people suffer from inflammatory bowel disease (IBD) worldwide, either in the form of ulcerative colitis or Crohn’s disease, and few effective long-term treatments are...
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Study shows BPA risk factor for inflammatory bowel disease
A recent study in a preclinical model of inflammatory bowel disease shows dietary exposure to bisphenol-A, or BPA, found in polycarbonate plastics and epoxy resins, can increase mortality and worsen its symptoms. Dr. Clint Allred (second from left) and colleagues in the laboratory. Credit: Texas A&M College of Agriculture and Life Sciences Dr. Clint Allred,...
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Role of transcriptional co-factor hints at possible inflammatory bowel disease treatment
Tokyo – Inflammatory bowel disease (IBD), including the two conditions ulcerative colitis and Crohn’s disease, results in long-term inflammation of the gut and is associated with dysregulation of the immune system. However, it is notoriously difficult to determine the cause of IBD, although genetic and environmental factors are implicated. To better understand disease development, researchers...
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Immune cells produce wound healing factor, could lead to new IBD treatment
Specific immune cells have the ability to produce a healing factor that can promote wound repair in the intestine, a finding that could lead to new, potential therapeutic treatments for inflammatory bowel disease (IBD), according to a new research study. The research team, led by Georgia State University and the University of Michigan, wanted to...