September 9, 2024 by David Nutt, Cornell University Sample overview. (A) Sample counts and distribution of hospital of origin for each disease group. “Other” indicates other hospitalized pediatric controls (B) Age distribution, (C) C-reactive protein (CRP) levels, (D) sex distribution, and (E) ICU status distribution for each sample group.RNA performs a number of biological duties,...
JUNE 25, 2024 by Walter and Eliza Hall Institute Atlas of necroptotic pathway expression in human intestinal crypts. Credit: WEHIFully automated diagnostic techniques, including liquid handling robots, are poised to improve the lives of millions of people living with inflammatory diseases worldwide. A landmark Walter and Eliza Hall Institute (WEHI) study has revealed new methods...
by Monash University Credit: Pixabay/CC0 Public Domain A recent study by Monash University has found that proteins found naturally in tick saliva, called evasins, can be modified to block the activity of important proteins in human inflammatory diseases such as arthritis, asthma and multiple sclerosis. The study, conducted at the Monash Biomedicine Discovery Institute, showed...
by The Scripps Research Institute Credit: Pixabay/CC0 Public Domain A team co-led by scientists at Scripps Research has found evidence that a compound contained in the medicinal and culinary herb rosemary could be a two-pronged weapon against the SARS-CoV-2 coronavirus that causes COVID-19. The scientists, in experiments described in a paper published January 6, 2022...
The circadian body clock generates 24-hour rhythms that keep humans healthy and in time with the day/night cycle. This includes regulating the rhythm of the body’s own (innate) immune cells called macrophages. When these cell rhythms are disrupted (due to things like erratic eating/sleeping patterns or shift work), the cells produce molecules which drive inflammation....
IMAGE: NEURAMINIDASE SUPPRESSES AUTOIMMUNE ARTHRITIS AND ENCEPHALOMYELITIS BY INHIBITING DENDRITIC CELL AND OSTEOCLAST ACTIVITY THROUGH REMOVAL OF SIALIC ACID, THEREBY EXPOSING ASIALO-BIANTENNARY N-GLYCAN (NA2) AND GENERATING INHIBITORY SIGNALS THROUGH DENDRITIC CELL IMMUNORECEPTOR (DCIR). CREDIT: YOICHIRO IWAKURA FROM TOKYO UNIVERSITY OF SCIENCE Immune cells play a key role in mediating inflammatory responses. Dysregulation in signaling mechanisms...
1. Live shingles vaccine shows safe, short-term efficacy for persons taking TNFis for inflammatory diseases A randomized controlled trial found that the live shingles, or varicella-zoster, vaccine was safe and showed short-term efficacy for participants also taking tumor necrosis factor inhibitors (TNFis) for a broad range of inflammatory disorders. These finding suggest that a live virus...
by WEHI Hallmarks of inflammation. An international team of researchers have uncovered a drug-like compound that blocks a crucial inflammatory pathway, potentially paving the way for a new treatment for a host of diseases—including COVID-19. WEHI’s Associate Professor Seth Masters and his research team discovered the compound could prevent up-regulation of CD14, a key inflammatory protein. The discovery was...
GEORGIA STATE UNIVERSITY ATLANTA–Targeted immunization against bacterial flagellin, a protein that forms the appendage that enables bacterial mobility, can beneficially alter the intestinal microbiota, decreasing the bacteria’s ability to cause inflammation and thus protecting against an array of chronic inflammatory diseases, according to a new study by the Institute for Biomedical Sciences and the Neuroscience...
A research team in Trinity has uncovered a critical role for a protein called ‘PKM2’ in the regulation of immune cell types at the heart of multiple inflammatory diseases. The work identifies PKM2 as a potential therapeutic target for treating a host of diseases mediated by over-active immune cells, such as psoriasis and multiple sclerosis. Credit: Trinity...
