A research team in Trinity has uncovered a critical role for a protein called ‘PKM2’ in the regulation of immune cell types at the heart of multiple inflammatory diseases. The work identifies PKM2 as a potential therapeutic target for treating a host of diseases mediated by over-active immune cells, such as psoriasis and multiple sclerosis. Credit: Trinity...
Tag: <span>inflammatory diseases</span>
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New insights into the release of molecules involved in inflammatory diseases
Image of a biopsy from the intestine of a mouse that has inflammatory bowel disease, a condition in which TNF-mediated inflammation is heavily implicated. In a recent study published in Cell Reports, a research team led by Colin Adrain, from the Instituto Gulbenkian de Ciência (IGC, Portugal), discovered the mechanism that controls the release of...
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New study reveals new drug target for gout and other inflammatory diseases
Particle-driven diseases sound exotic and include things like silicosis and asbestos, but actually also include much more common diseases like Alzheimer’s, gout and even atherosclerosis. A new report published online in the Journal of Leukocyte Biology suggests a potential drug target for particle-driven diseases like these and many others. Specifically, the study reveals that particle-induced cell death...
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