Dive Brief: India’s drug regulator has granted an emergency approval to the antibody drug itolizumab to treat the potentially deadly immune response, cytokine release syndrome, that appears to affect some patients hospitalized with acute respiratory distress related to COVID-19. The Drugs Controller General of India cleared the treatment for use after itolizumab, alongside standard of...
INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) Approximately 5% of people with Covid-19 progress to a severe or critical form, including the development of severe pneumonia that progresses to acute respiratory distress syndrome. While these forms sometimes occur early in the course of the disease, clinical observations generally describe a two-stage...
Context and Significance Respiratory viral diseases, such as seasonal influenza or COVID-19, are deadly scourges on society. Immunometabolic therapies may be important tools to reduce the burden of death and long-term disability caused by pandemic viruses. Here, we describe the biological effects of ketone bodies, natural metabolites produced during fasting or carbohydrate restriction, that maintain...
Anne Borden King had already battled online health misinformation as a parent of a child with autism. Then, as a patient, she was barraged on Facebook by bogus cancer “cure” advertisements after posting about her diagnosis. Borden, a co-founder of the Campaign Against Phony Autism Cures, talked to me about what we and Facebook can...
Why do we age? What exactly happens in the body? And: Can something be done about it? These are questions that have occupied science since time immemorial. The pharmacists Alexandra K. Kiemer and Jessica Hoppstädter from the Saarland University have not found a philosophical stone. But: they have uncovered processes in the immune system that...
By Rich Haridy July 06, 2020 New research from the University of South Carolina is uncovering exactly how non-alcoholic fatty liver disease (NAFLD) influences the neurological conditions associated with Alzheimer’s disease. The study describes how a certain protein produced in the liver can travel to the brain and trigger neuroinflammation. Several recent studies have drawn...
by Salk Institute A histology image showing inflammation in colon epithelium. Weakening of regulatory T cell function induces infiltration of immune cells (small blue dots) into colon epithelium (blue layer) and causes colitis. Credit: Salk Institute The human immune system is a finely-tuned machine, balancing when to release a cellular army to deal with pathogens,...
Physical exercising is extremely healthy for your body and mind. However, intense exercising is likely to cause some pains and, sometimes, even injuries. Runners often use non-steroidal anti-inflammatories (NSAIDs) to ease post-exercise aches, pains or injuries, but scientists from the Queen Mary’s University London and the University of Birmingham say that this might be a...
Children with COVID-19 may present with new neurological symptoms involving the central and peripheral nervous systems, and splenial changes on imaging, according to a study published online July 1 in JAMA Neurology. Omar Abdel-Mannan, M.D., from Great Ormond Street Hospital for Children in London, and colleagues reported neurological manifestations of children with COVID-19 in a...
by University of Virginia Doctors can examine COVID-19 patients’ blood to identify those at greatest risk of severe illness and to pinpoint those most likely to need a ventilator, new research from the University of Virginia School of Medicine suggests. The discovery could lead to new treatments to prevent deadly “cytokine storms” seen in severe...
