Tag: <span>inhibition</span>

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Dual inhibition of cAMP responsive element binding protein 3 on AKT signaling supresses the progression of hepatocellular carcinoma

NEWS RELEASE 2-JUL-2024 Peer-Reviewed PublicationSICHUAN INTERNATIONAL MEDICAL EXCHANGE AND PROMOTION ASSOCIATION This study is led by Prof. Bixiang Zhang, Dr. Zhao Huang, Prof. Zeyang Ding, Dr. Huifang Liang (Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology). The experimental part was mainly conducted by Dr. Yi He, Dr. Shenqi Han,...

Scientists develop an agent capable of selectively inhibiting the body’s stress response
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Scientists develop an agent capable of selectively inhibiting the body’s stress response

by Daniel Meierhans, ETH Zurich The DEGs we identified upon 2 h, and 18 h of DEX treatments in A549 cells align with the other existing RNAseq and ChIP-seq datasets. Credit: Nature Communications (2023). DOI: 10.1038/s41467-023-44031-2Stress isn’t merely an oppressive feeling we experience when we’re overwhelmed; it’s the body’s natural reaction to acute or persistent strain. This stress...

Why drugs sometimes cause receptor potentiation rather than inhibition
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Why drugs sometimes cause receptor potentiation rather than inhibition

by  Ruhr-Universitaet-Bochum Using a dedicated application technique and electrophysiological measurements, the researchers rapidly activated the glutamate receptors. The picture shows a setup for patch-clamp electrophysiology. Glutamate is the messenger substance the brain uses to pass on excitatory signals. Receptors for this neurotransmitter are a promising target for drug development, as they are involved in many pathological...