by Ruhr-Universitaet-Bochum Credit: Unsplash/CC0 Public Domain Peripheral nerves refer to nerves that lie outside of the brain and spinal cord. They run throughout the entire body. These bundles of nerve fibers can be damaged in the event of blunt or sharp force trauma due to accidents, as well as during surgery. Injuries to the peripheral nerves...
by Yale School of Engineering and Applied Science Credit: Pixabay/CC0 Public Domain In response to brain injury, neural stem cells cluster and migrate to the site of injury. The clustering is key—without it, the cells don’t travel. But what causes it? To investigate, Yale researchers created a 3-D model of the brain’s workings. The results of the...
by Jennifer Michalowski, University of Utah Health Sciences Credit: CC0 Public Domain Following a brain-injuring bump or blow to the head, brain cells and blood vessels typically swell. This can lead to a potentially life-threatening increase in pressure inside the skull, and managing swelling is critical for patients with traumatic brain injuries (TBIs). But researchers at...
Researchers here provide an interesting demonstration of the beneficial role of transient cellular senescence in injury. Applying senolytics to selectively destroy senescent cells immediately following traumatic injury greatly worsens the consequences. Senescent cells are harmful when they build up and linger in tissues over the course of later life. The signaling they generate is useful in the short-term, such as by mobilizing...
by Universitaet Mainz Remyelination in the spinal cord after experimental focal degradation of myelin sheaths, simulating a lesion caused by multiple sclerosis. In young adults, the myelin sheath (dark rings) around axons (light gray circular structures) can be rebuilt, but this process is not fully efficient and its efficiency decreases sharply with age and as...
Disney lab collaboration reawakens heart cells’ silenced VEGF-A healing system by targeting non-coding RNA SCRIPPS RESEARCH INSTITUTE CHEMISTRY PROFESSOR MATTHEW DISNEY, PHD, IN HIS LAB AT SCRIPPS RESEARCH IN JUPITER, FLORIDA. DISNEY AND HIS GRADUATE STUDENT, HAFEEZ HANIFF, DEVELOPED A COMPOUND THAT ACTS ON NON-CODING RNA TO… view more CREDIT: MATTHEW STURGESS FOR SCRIPPS RESEARCH...
Nearly three-quarters of older adults with dementia have filled prescriptions for medicines that act on their brain and nervous system, but aren’t designed for dementia, a new study shows. That’s despite the special risks that such drugs carry for older adults – and the lack of evidence that they actually ease dementia-related behavior problems that...
Even after all of their symptoms are gone, people who have had a concussion take longer to regain complex reaction times, the kind you need in most real-life driving situations on the road, according to a preliminary study released today that will be presented at the American Academy of Neurology’s Sports Concussion Virtual Conference from...
Harvard Medical School researchers at Boston Children’s Hospital and Brigham and Women’s Hospital will soon begin testing an existing drug, dornase alfa, in patients with severe COVID-19 pneumonia and respiratory failure. The randomized, controlled clinical trial aims to enroll 60 adults and children over age 3 who require mechanical ventilation. Dornase alfa, also known as...
by Children’s Hospital Boston Children’s Hospital tested PR1P in lung cells and mouse models of emphysema, they found that it protected VEGF from being degraded, prevented cell death, and protected the lung. Credit: Hao Wu, PhD, Boston Children’s Hospital Emphysema is a progressive, debilitating lung disease in which the lung’s breathing sacs, or alveoli, enlarge,...
