by Jim Schnabel, Cornell University Graphical Abstract. Credit: Cell Reports Medicine (2024). DOI: 10.1016/j.xcrm.2024.101431Although it is one of the oldest medications used to treat patients with inflammatory bowel disease (IBD) and an effective treatment for an associated arthritis condition called spondyloarthritis (SpA), sulfasalazine’s mechanism of action has been unclear. Now, researchers at the Jill Roberts Center...
by European Synchrotron Radiation Facility The structure of the ACAD9-ECSIT_CTER complex (ECSIT in red). An international team of researchers, led by the ESRF, have elucidated the structure of the ACAD9-ECSIT_CTER complex, by using cryo-EM techniques. This complex is important in the correct functioning of the energy-producing machinery in mitochondria. Credit: ESRF/M. Soler López. Credit: ESRF/M. Soler...
By Dr. Liji Thomas, MD Reviewed by Aimee Molineux The human body interacts with the outside world through its sense organs, of which the largest is the skin. The skin is home to a world of microbes, living mostly as commensals (microbes with neutral or beneficial interactions with the skin). They play a part in...
by Massachusetts Institute of Technology Credit: Pixabay/CC0 Public Domain Every day, billions of red blood cells pass through the spleen, an organ that is responsible for filtering out old or damaged blood cells. This task is made more difficult when the blood cells are misshapen, as they are in patients with sickle cell disease, which...
by Erik Robinson, Oregon Health & Science University Recovery from depression is accelerated by Ca2+ binding to presynaptic SYT3. Credit: Nature (2022). DOI: 10.1038/s41586-022-05337-1 Scientists at Oregon Health & Science University have identified a long-sought gene-encoded protein that enables the brain to communicate a broad range of signals across gaps between neurons, known as synapses. The discovery published...
By Dr. Sanchari Sinha Dutta, Ph.D.Reviewed by Aimee Molineux Polycystic ovary syndrome (PCOS) is a type of endocrine disorder characterized by an abnormal menstrual cycle and the presence of multiple small cysts on the ovaries. The condition is developed due to excessive production of male sex hormones (androgens) by the ovaries. Image Credit: pathdoc/Shutterstock Despite not having...
