by Baker Heart & Diabetes Institute Pharmacological inhibition of EZH2 catalyzes pancreatic progenitor activation and β-cell maturation. The schematic outlines the progression from pancreatic multipotent progenitors to mature insulin-secreting β-cells, highlighting the regulatory target of EZH2 inhibitors, GSK126 and Tazemetostat. Credit: Signal Transduction and Targeted Therapy (2024). DOI: 10.1038/s41392-023-01707-xResearchers are zeroing in on the ultimate...
Tag: <span>insulin</span>
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Real-Time CGM Plus Insulin Pump Best for Type 1 Diabetes
Miriam E. Tucker Youth with type 1 diabetes who use real-time continuous glucose monitoring (rtCGM) and an insulin pump spend more time in target glucose range than those using intermittently scanned CGM (isCGM) and/or multiple daily insulin injections, new data show. In the multinational cohort study of more than 4500 people younger than age 21...
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Nanoclusters of Insulin Can Control Insulin Activity
A recently published study shows how nanoclusters of insulin can control insulin activity. Insulin pen, needle visible with a drop of insulin coming out – illustrative photo. Insulin nanoclusters could lead to new types of diabetes therapies. Image credit: Dennis Klicker via Unsplash, free license The results can lead to new types of insulin drugs,...
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Amazon Pharmacy expands insulin manufacturer coupons
Rebecca Pifer Senior Reporter Courtesy of Amazon Dive Brief: Amazon on Tuesday added more than 15 new manufacturer-sponsored coupons for insulin brands and diabetes care products to its online pharmacy. The additions bring Amazon’s manufacturer coupons that are automatically applied during check-out for eligible customers to 36. The new coupons include some of the most commonly prescribed...
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33% of Type 1 Diabetes Patients Insulin-Free With Stem Cells
Miriam E. Tucker July 03, 2023 SAN DIEGO — An investigational allogeneic stem cell–derived pancreatic islet cell replacement therapy (VX-880, Vertex Pharmaceuticals) continues to show promise as a treatment for type 1 diabetes, according to the latest data, from six patients thus far. Two of the six are insulin-independent beyond 1 year after receiving the VX-880 infusions,...
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33% of Type 1 Diabetes Patients Insulin-Free With Stem Cells
Miriam E. Tucker July 03, 2023 SAN DIEGO — An investigational allogeneic stem cell–derived pancreatic islet cell replacement therapy (VX-880, Vertex Pharmaceuticals) continues to show promise as a treatment for type 1 diabetes, according to the latest data, from six patients thus far. Two of the six are insulin-independent beyond 1 year after receiving the VX-880 infusions,...
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A plant-based, oral delivery of insulin regulates blood sugar levels similar to natural insulin: Study
by Lauren Rebecca Thacker, University of Pennsylvania Graphical Abstract: Current and future insulin drug delivery methods and percentage global usage: (A) Subcutaneous insulin injections: Syringes and vials—9.6%. (B) Transdermal Insulin Pen—85.6%. (C) Implantable insulin pump—< 5% (D) Insulin Inhalers—<5% (E) Transdermal insulin Patches <5% people. (F) Oral Delivery using micro or nano particles—in development. (G) Oral...
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Longer shelf life for insulin has major bearing on global health
by Swedish Research Council Relative potency and total concentration of insulins at each timepoint Relative potency measured by high-performance liquid chromatography-ultraviolet (shaded in black), and relative concentration measured by nuclear magnetic resonance (shaded in blue), of the control insulins after storage in refrigerator (squares), and insulins stored in clay pots (circles) or boxes (triangles) for 1,...
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Could insulin come in a pill? How a molecule that mimics insulin may advance diabetes research
by Walter and Eliza Hall Institute A 3D image showing how an insulin mimicking molecule (purple) interacts with part of the insulin receptor (grey) to turn in on. Once activated, the receptor directs cells to soak up glucose when the body’s sugar levels are too high. Credit: WEHI. WEHI researchers in Melbourne have answered a...
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New islet transplant method leads to insulin independence
by Perelman School of Medicine at the University of Pennsylvania A pancreatic islet from a mouse in a typical position, close to a blood vessel; insulin in red, nuclei in blue. Credit: Generated in the Solimena lab, Paul Langerhans Institute Dresden More than half of the most seriously affected type 1 diabetes patients achieved years...