Senescent cells accumulate with age throughout the body, and contribute directly to the onset and progression of a wide range of age-related conditions. While never present in large numbers in comparison to normal somatic cells, senescent cells are metabolically active, secreting signals that provoke chronic inflammation, altered cell behavior, and numerous forms of tissue dysfunction....
Tag: <span>insulin resistance</span>
Post
Signaling molecules called EETs may improve treatment for insulin resistance
by Bill Snyder, Vanderbilt University Medical Center Credit: CC0 Public Domain Analogs of signaling molecules called EETs may improve treatment of insulin resistance, a primary risk factor for development of Type 2 diabetes and cardiovascular disease, according to a new paper by researchers at Vanderbilt University Medical Center. Ambra Pozzi, Ph.D., and colleagues previously reported that EETs...
Post
Researchers identify potential cause and treatment for obesity and insulin resistance
by Monash University Credit: Shutterstock Monash University researchers have shown for the first time that mesenteric (gut) lymphatic dysfunction is a potential cause of and therapeutic target for obesity and insulin resistance. The groundbreaking study, published in Nature Metabolism, identified a profoundly damaging cycle in which a high fat diet promotes dysfunction of the mesenteric lymphatics, that in turn leads to...
Post
Differences in cellular signaling offer clues to insulin resistance
by Max Bingham, Harvard Medical School Credit: Pixabay/CC0 Public Domain In what could be a starting point for new therapeutics to tackle insulin resistance, a major driver of type 2 diabetes and metabolic syndrome present in 20–30 percent of the general U.S. population, researchers recently found that insulin resistance in the general population seems likely to be caused...
Post
Blocking a protein in liver cells protects against insulin resistance, fatty liver disease
by University of California, Los Angeles Mitochondria inside liver cells (hepatocytes). Credit: Mayuko Segawa, Liesa lab at UCLA Health A new multi-institution study led by a team of researchers at the David Geffen School of Medicine demonstrated that blocking a protein called ABCB10 in liver cells protects against high blood sugar and fatty liver disease in obese mice....
Post
Connecting the dots between insulin resistance, unhealthy blood vessels and cancer
Animal studies examine risk factors that may overlap between colorectal cancer and cardiovascular disease Christian Rask-Madsen, M.D., Ph.D., is assistant investigator in the Section on Vascular Biology and Complications at Joslin Diabetes Center, and assistant professor at Harvard Medical School. Over the decades, scientists have repeatedly shown that patients with increased levels of the hormone...
- 1
- 2