Miriam E. Tucker July 03, 2023 SAN DIEGO — An investigational allogeneic stem cell–derived pancreatic islet cell replacement therapy (VX-880, Vertex Pharmaceuticals) continues to show promise as a treatment for type 1 diabetes, according to the latest data, from six patients thus far. Two of the six are insulin-independent beyond 1 year after receiving the VX-880 infusions,...
Tag: <span>insulin</span>
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33% of Type 1 Diabetes Patients Insulin-Free With Stem Cells
Miriam E. Tucker July 03, 2023 SAN DIEGO — An investigational allogeneic stem cell–derived pancreatic islet cell replacement therapy (VX-880, Vertex Pharmaceuticals) continues to show promise as a treatment for type 1 diabetes, according to the latest data, from six patients thus far. Two of the six are insulin-independent beyond 1 year after receiving the VX-880 infusions,...
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A plant-based, oral delivery of insulin regulates blood sugar levels similar to natural insulin: Study
by Lauren Rebecca Thacker, University of Pennsylvania Graphical Abstract: Current and future insulin drug delivery methods and percentage global usage: (A) Subcutaneous insulin injections: Syringes and vials—9.6%. (B) Transdermal Insulin Pen—85.6%. (C) Implantable insulin pump—< 5% (D) Insulin Inhalers—<5% (E) Transdermal insulin Patches <5% people. (F) Oral Delivery using micro or nano particles—in development. (G) Oral...
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Longer shelf life for insulin has major bearing on global health
by Swedish Research Council Relative potency and total concentration of insulins at each timepoint Relative potency measured by high-performance liquid chromatography-ultraviolet (shaded in black), and relative concentration measured by nuclear magnetic resonance (shaded in blue), of the control insulins after storage in refrigerator (squares), and insulins stored in clay pots (circles) or boxes (triangles) for 1,...
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Could insulin come in a pill? How a molecule that mimics insulin may advance diabetes research
by Walter and Eliza Hall Institute A 3D image showing how an insulin mimicking molecule (purple) interacts with part of the insulin receptor (grey) to turn in on. Once activated, the receptor directs cells to soak up glucose when the body’s sugar levels are too high. Credit: WEHI. WEHI researchers in Melbourne have answered a...
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New islet transplant method leads to insulin independence
by Perelman School of Medicine at the University of Pennsylvania A pancreatic islet from a mouse in a typical position, close to a blood vessel; insulin in red, nuclei in blue. Credit: Generated in the Solimena lab, Paul Langerhans Institute Dresden More than half of the most seriously affected type 1 diabetes patients achieved years...
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BIONIC PANCREAS DELIVERS THE RIGHT DOSE OF INSULIN ON ITS OWN
In the study in the New England Journal of Medicine, researchers found the wearable device was better at managing blood glucose levels than existing standard-of-care methods. Your pancreas is like a little digestive engine, working hard to keep your body fueled and running. Just six inches long, it’s responsible for turning lunch into the energy that...
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SMNDC1 loss induces alpha cells to produce insulin
CEMM RESEARCH CENTER FOR MOLECULAR MEDICINE OF THE AUSTRIAN ACADEMY OF SCIENCES IMAGE: IMMUNOFLUORESCENCE IMAGES OF ALPHA CELLS HIGHLIGHTING INDUCTION OF INSULIN PROTEIN UPON LOSS OF SMNDC1 CREDIT: TAMARA CASTEELS, PUBLISHED IN CELL REPORT 2022. Beta cells in the pancreas are responsible for producing the vital hormone insulin. In diabetes, these cells are either destroyed...
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A new pathway to the regeneration of insulin could mean a major breakthrough in diabetes treatment
by could mean a major breakthrough toward new therapies for Type 1 and Type 2 diabetes, Monash University Credit: Pixabay/CC0 Public Domain A world-first study by Monash University, in Melbourne, Australia has discovered a pathway to the regeneration of insulin in pancreatic stem cells, a major breakthrough toward new therapies to treat Type 1 and Type...
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Key enzyme identified in protection of beta cells and regulation of insulin
by American Physiological Society High-resolution model of six insulin molecules assembled in a hexamer. Credit: Isaac Yonemoto/Wikipedia Physiologists at the Medical College of Wisconsin have identified the enzyme thioredoxin reductase as playing a key role in protecting beta cells from oxidative stress and in the regulation of insulin secretion. Researchers also show in this study that...