The chronic pain experienced by a number of patients with diabetes has widely been assumed to originate from damage to blood vessels or to local tissue surrounding neurons caused by high blood-sugar levels. However, a new study reports that in fruit flies, this pain hypersensitivity results instead from disrupted insulin signaling in pain sensory neurons....
Tag: <span>insulin</span>
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New research sheds light on weight gain, stress and our circadian rhythms
A recent study sheds new light on why people gain weight from long-term stress and disruption to their circadian rhythms. It also helps to explain weight gain from the use of glucocorticoid drugs, which are often used in the treatment of rheumatoid arthritis and asthma. For the first time scientists think they have a molecular...
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Resistance exercise improves insulin resistance, glucose levels
A new study suggests that resistance exercise may improve indicators of type 2 diabetes by increasing expression of a protein that regulates blood sugar (glucose) absorption in the body. The paper, published ahead of print in the American Journal of Physiology-Endocrinology and Metabolism, was chosen as an APSselect article for April. People with type 2 diabetes...
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A new role for insulin as a vital factor in maintaining stem cells
New research conducted at the stem cell centre, DanStem, at the University of Copenhagen shows that insulin is a key determinant of embryonic stem cell potency in mammals New research conducted at the stem cell centre, DanStem, at the University of Copenhagen shows that insulin is a key determinant of embryonic stem cell potency in...
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New measure of insulin-making cells could gauge diabetes progression, treatment
Baseline PET scan shows uptake of manganese chloride tracer in mouse pancreas, in research at the University of Wisconsin–Madison department of radiology. Signal is greatly reduced in mice given a drug that inhibits insulin production, and conversely, intensified in mice given a stimulator of insulin production. Researchers at the University of Wisconsin-Madison have developed a...
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Transforming skin cells to insulin
Researchers at the University of Bergen have transformed skin puncture cells from diabetes patients into insulin producing cells, using stem cell techniques. The researchers’ aim is to transplant these cells under the skin of people with diabetes. “This study is a step towards discovering how “stand-in” cells can secrete insulin in the body,” says Professor...
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Type 1 diabetes: Almost half of patients produce insulin
Type 1 diabetes is often described as a condition in which the body fails to produce the hormone insulin. New research, however, provides further evidence that not all insulin production is lost with the condition, and this may be down to an anti-inflammatory protein. Researchers from Uppsala University in Sweden found that nearly half of...
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Federal lawsuit accuses three insulin manufacturers of conspiring together to raise their prices as research finds cost increased 120% over four years
Federal lawsuit accuses Sanofi SA, Novo Nordisk and Eli Lilly & Co of simultaneously increasing the price of insulin Research firm found prices of drug from three companies increased between 99 and 120 percent from 2012 to 2016 Lawsuit plaintiffs claim that some skipped meals or underdosed their insulin because they could not afford treatment...
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Chemically modified insulin is available more quickly
Binding of the insulin analog (green) to the receptor (light blue). The receptor’s surface is shown in transparent gray. Replacing a hydrogen atom by an iodine atom in insulin, the hormone retains its efficacy but is available more rapidly to the organism. Researchers at the University of Basel were able to predict this effect based...