Many nerve cells in the brain region hypothalamus have unexpected origins and go through complex development programs, where millions of neurons assemble into a precisely knit network by birth. That is according to a study by researchers at Karolinska Institutet in Sweden and the Medical University of Vienna published in the journal Nature. The findings...
Highlights Cryopreserved human iPSC-mDA neurons retain high viability and midbrain lineage iPSC-mDA neurons secrete dopamine and possess typical electrophysiological parameters Grafted iPSC-mDA neurons survive and innervate rodent and monkey PD models Cryopreserved iPSC-mDA neurons reverse functional motor deficits in 6-OHDA rats Summary A major challenge for clinical application of pluripotent stem cell therapy for Parkinson’s...
