Edited by Javed Choudhury December 04, 2024 5354 Added to Email Alert TOPLINE: Patients with serum ferritin levels higher than 1000 μg/L show a 91% increased risk for any fracture, with a doubled risk for vertebral and humerus fractures compared with those without iron overload. METHODOLOGY: TAKEAWAY: IN PRACTICE: “The main clinical message from our...
Tag: <span>iron</span>
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Regulating iron overload: Liraglutide’s potential benefits
By Dr. Priyom Bose, Ph.D.Reviewed by Benedette Cuffari, M.Sc. Study: Liraglutide Impacts Iron Homeostasis in a Murine Model of Hereditary Hemochromatosis. Image Credit: Peter Togel / Shutterstock.com A recent Endocrinology study assesses the role of liraglutide in regulating iron metabolism in a mouse model of hereditary hemochromatosis, diet-induced obesity, and glucose intolerance. Treatment options for...
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Scientists describe how iron helps drive tumor development in colorectal cancer
by Michael Haederle, University of New Mexico TFRC is increased in human CRC and is positively correlated with the CTNNB1 protein expression. Detection of TFRC expression in human normal (n = 5–8) and tumor (n = 8) colon tissues by A) qPCR analysis, B) immunoblotting analysis and (C) quantification, and D) immunofluorescence staining and E)...
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Iron buildup in brain linked to higher risk for movement disorders
by University of California – San Diego In these brain scans, blue areas indicate regions with iron accumulation in individuals with two copies of the hemochromatosis risk gene. These regions also play a role in movement. Credit: UC San Diego Health Sciences A disorder called hereditary hemochromatosis, caused by a gene mutation, results in the body...
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Age-related cognitive decline linked with buildup of iron in the brain
By Rich Haridy February 01, 2022 New research homes in on a mechanism that could explain how brain iron levels increase with age Researchers at Northwestern Medicine have uncovered a mechanism they say contributes to the age-related accumulation of iron in the brain, a process some argue is a cause of cognitive decline. The study...