(Adobe Stock)Tuesday, 24 October 2023 04:38 PM EDT The party drug ketamine has gotten a lot of notice for its potential to help people with severe and persistent depression who haven’t responded to other treatments. But a new study has discovered the drug’s effect may be in the heads of patients who take it. Researchers...
Tag: <span>Ketamine</span>
Post
Blind ketamine study yields surprising placebo effect
By Paul McClure A new study into using ketamine to treat depression has yielded surprising results. Despite the unique way in which the researchers ensured the trial was ‘blind’, those who received a placebo had the same improvement in symptom severity as those administered the psychoactive drug. Clinical trials of psychoactive drugs like LSD, MDMA and...
Post
Ketamine Can Treat Depression as Effectively as Electroconvulsive Therapy
05 June 2023 By CARLY CASSELLA (Todorean Gabriel/Getty Images) The “dissociative anesthetic” ketamine looks ever more promising as a safe and effective treatment for intractable depression. A new randomized trial from researchers in the United States has shown that injections of ketamine are at least as effective as electroconvulsive therapy (ECT) when treating non-psychotic forms of major depression. After starting...
Post
New insights on how ketamine can lessen symptoms of depression but also cause dissociative side effects
by Noah Brown, Massachusetts General Hospital Study protocol and intracranial EEG power changes for example channels. a Study protocol. b Power spectrogram (dB) for three example channels: inferior frontal, middle temporal and occipital from Subject #9. c Power spectrum averaged across time during baseline, ketamine, and propofol conditions for the three example channels. CADSS: clinician-administered dissociative...
Post
New study reveals ketamine could be effective treatment for cocaine-use disorders
by Case Western Reserve University Comparison of gender and race in remission from CUD among patients taking ketamine as an antidepressant. Credit: Addiction (2023). DOI: 10.1111/add.16168 As cocaine use continues to climb across the United States, scientists have struggled to develop an effective pharmacological approach to treat the devastating disorder. But by seamlessly combining artificial intelligence(AI), human intelligence, clinical...
Post
Ketamine found to increase brain noise
by Anastasia Lobanova, National Research University Higher School of Economics Izhikevich, Edelman / Proceedings of the National Academy of Sciences of the United States of America An international team of researchers including Sofya Kulikova, Senior Research Fellow at the HSE University-Perm, found that ketamine, being an NMDA receptor inhibitor, increases the brain’s background noise, causing higher entropy of incoming sensory signals...
Post
Study gives a peek at how ketamine acts as ‘switch’ in the brain
by Perelman School of Medicine at the University of Pennsylvania KET induces a switch in the active population of L2/3 neurons in S1. Credit: Nature Neuroscience (2022). DOI: 10.1038/s41593-022-01203-5 Ketamine, an established anesthetic and increasingly popular antidepressant, dramatically reorganizes activity in the brain, as if a switch had been flipped on its active circuits, according to a...
Post
Ketamine Linked to Reduced Suicidal Thoughts, Depression, Anxiety
Pauline Anderson September 14, 2022 Ketamine infusions can help reduce symptoms of suicidal ideation, depression, and anxiety in patients with treatment-resistant depression (TRD), new research suggests. Results from a retrospective chart review analysis, which included more than 400 participants with TRD, illustrate that ketamine is a safe and rapid treatment in a real-world patient population, lead author...
Post
Ketamine may ease depression in as little as 4 hours by updating negative thoughts
Depression impacts millions of people in the United States alone, but the disorder can be challenging to treat. Some people do not respond well to the typical medications or therapies doctors use to treat depression. So, experts are constantly researching new ways to help improve treatment options for people with depression. A new study published...
Post
Three years after clinical trial, ketamine provides hope for severely depressed
by Thomas Curwen One 10 ml vial of 1000 mg ketamine. Credit: Psychonaught/Wikipedia Patients arriving at Dr. Philip O’Carroll’s Newport Beach office for their first ketamine treatment are in pain and often lost. They have visited other doctors, tried other solutions and are ready for what is considered a last resort. They are led to...