by University of Oxford Inhibition of glucokinase prevents the effects of chronic hyperglycaemia. a Schematic showing how mannoheptulose (MH) inhibits glucose metabolism. b, c Insulin secretion (b) and insulin content (c) in LG-cells and HG-cells cultured for 48 h ± 10 mM mannoheptulose (MANNO) and then stimulated with 2 mM or 20 mM glucose. Mannoheptulose was omitted during the assay (n = 3...
