Peer-Reviewed Publication INSTITUTE FOR RESEARCH IN BIOMEDICINE (IRB BARCELONA) Barcelona, 30 January 2024 – Protein degraders, a novel approach in drug discovery, show promise to tackle diseases previously thought to be untreatable. Unlike traditional drugs that block specific protein functions, degraders alter the cell’s natural degradation process so that it can remove disease-relevant proteins. However,...
Tag: <span>key mechanism</span>
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Researcher identifies key mechanism in Parkinson’s disease
by Anna Zarra Aldrich, University of Connecticut Proper regulation of LRRK2 levels is important for Parkinson’s disease (PD). ATIC, a purine biosynthesis pathway enzyme, and its substrate precursor AICAr regulate LRRK2 mRNA levels via an mRNA decay pathway. AICAr suppresses LRRK2 expression and can rescue LRRK2-induced dopaminergic neurodegeneration and neuroinflammation in PD animal models. Credit: The EMBO...
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Researchers reveal key mechanism of natural killer cell dysfunction
by Liu Jia, Chinese Academy of Sciences Intratumoral NK cells lack abundant membrane protrusions. Credit: Nature Immunology (2023). DOI: 10.1038/s41590-023-01462-9 A team has revealed the key mechanism of the loss of membrane protrusions on intratumoral natural killer (NK) cells, which impairs their ability to recognize and kill tumor cells, providing a new strategy for NK cell-based immunotherapy. This...
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Scientists identify key mechanism controlling skin regeneration
It’s sunburn season. Many of us have experienced the pain and peeling from unprotected sun exposure. Still, we may not focus on a remarkable and vital part of the process: skin regeneration as the damaged tissue is replaced with new. Even without sunburn, the outer layer of skin, the epidermis, is constantly turning over to replace...
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Scientists reveal new evidence of key mechanism in Alzheimer’s
by Rutgers University Graphical abstract. Credit: Cell Stem Cell (2022). DOI: 10.1016/j.stem.2022.06.007 Rutgers scientists have found more clear-cut evidence of how the destructive proteins linked to Alzheimer’s disease attack human brain cells and destroy surrounding tissue. In one of the first studies of its kind examining human brain cells grown in a mouse brain, researchers identified a pivotal mechanism that...
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Researchers identify key regulatory mechanism in inflammation
by Kathy Keatley Garvey, UC Davis A control burn at the University of California, Davis. Credit: Kathy Keatley Garvey Every year some 10,000 burn victims in the United States undergo an acute inflammatory reaction and die of burn-related infections, according to the Centers for Disease Control and Prevention. Now a newly published study by a...