by Columbia University Irving Medical Center Cross-ancestry GWAS for IgAN. Credit: Nature Genetics (2023). DOI: 10.1038/s41588-023-01422-x The cause of a common kidney disease likely lies outside the kidney, according to a new study led by Columbia University researchers. The study, which uncovered 16 new locations in the genome linked to immunoglobulin A (IgA) nephropathy, confirms an earlier hypothesis that...
by Jeff Hansen, University of Alabama at Birmingham Credit: Pixabay/CC0 Public Domain Macrophages are immune cells that engulf and digest pathogens, cancer cells or cellular debris. The kidneys—like other tissues in the body—contain kidney resident macrophages, or KRMs, from the time of birth. These KRMs protect the kidney against infection or injury and help maintain tissue...
by Beth Miller, Washington University in St. Louis Researchers from McKelvey School of Engineering and the School of Medicine have created a technology that shows them how changes to the kidney associated with diabetes and elevated blood sugar affect the mechanical function of podocytes and their ability to recover, which has potential toward finding new treatments...
by European Society of Cardiology Credit: Pixabay/CC0 Public Domain In patients with advanced chronic kidney disease and chronic coronary disease, an invasive strategy does not reduce the five-year risk of death compared to a conservative strategy. That’s the finding of late breaking research presented in a Hot Line session on 29 August at ESC Congress 2022. Previous trials...
When medications and lifestyle accommodations stop helping someone fight advanced kidney disease, the person’s path forward narrows appreciably. Kidney doctors typically prescribe dialysis treatment, which, with luck, will extend the patient’s life until they qualify for an organ transplant. There exists another path, though, in which the patient recognizes the paucity of available donor organs, the...
by Karolinska Institutet Schematic of oxygen-dependent regulation of mitochondrial content within the von Hippel–Lindau syndrome. a, Genotype–phenotype correlation in cancers arising in the VHL syndrome and its association with regulation of HIFα and mitochondrial content. Note that the Cuvash polycythaemia mutation VHLR200W shows total absence of tumor development despite increased HIFα signaling and appears normal with...
by Brigham and Women’s Hospital Credit: Pixabay/CC0 Public Domain Chromophobe renal cell carcinoma (ChRCC) is a rare form of kidney cancer for which there are currently no proven treatments for metastatic or unresectable disease. In a study led by investigators from Brigham and Women’s Hospital, researchers report the first evidence that ChRCC can be targeted with...
by Stevens Institute of Technology Schematic design of the microfluidic printhead and the numerical modeled parameters. (a) The schematic figure of the hollow microfiber fabrication system using the microfluidic channel, (b) The schematic figure of the solid microfiber fabrication system using the microfluidic channel. (d–i) Velocity field, pressure field, and shear rate field in the...
The Kidney Project’s implantable bioartificial kidney, one that promises to free kidney disease patients from dialysis machines and transplant waiting lists, took another big step toward becoming reality, earning a $650,000 prize from KidneyX for its first-ever demonstration of a functional prototype of its implantable artificial kidney. KidneyX is a public–private partnership between the U.S. Department of...
TRANSLATIONAL RESEARCH INSTITUTE Following a large-scale clinical trial, researchers have found that lanthanum carbonate does not reduce the risk of cardiovascular disease developing in patients with chronic kidney disease. The drug is routinely prescribed to patients with chronic kidney disease to help reduce the risk of both bone disease and cardiovascular disease, with cardiovascular disease...
