Written by Hindu Rao, PharmD, APh, BCACP | Reviewed by Katie E. Golden, MD Updated on April 27, 2023 Key takeaways: Certain medications, called nephrotoxic medications, can damage your kidneys. This can make it harder for your kidneys to filter waste and other substances from your bloodstream. Nonsteroidal anti-inflammatory drugs (NSAIDs), diuretics, and angiotensin-converting enzyme...
by National University of Ireland, Galway Credit: Pixabay/CC0 Public Domain University of Galway, in collaboration with the NEPHSTROM Consortium, has announced promising results from a new cell therapy trial for people living with diabetes. The NEPHSTROM clinical trial is taking the first steps to investigate the value of a novel cell therapy for adults who...
by Massachusetts General Hospital Credit: Pixabay/CC0 Public Domain To a certain extent, kidneys have the capacity to repair themselves after being injured, but a switch can occur from such intrinsic repair to incomplete repair that leads to irreversible damage and chronic kidney disease (CKD). A team led by researchers at Massachusetts General Hospital (MGH) recently...
By Elizabeth Cooney March 2, 2022 Reprints Kidney organoids with markers of nephrons (purple, light blue, green) and stroma (red and yellow). Researchers used the miniature models to study when kidney damage turns irreversible.N. GUPTA, ET AL., SCIENCE TRANSLATIONAL MEDICINE Chronic kidney disease is a serious medical problem that changes the lives of about 13%...
TOKYO METROPOLITAN UNIVERSITY IMAGE: HYPEROSMOTIC STRESS LEADS TO A REORGANIZATION OF ACTIN STRUCTURE IN TUBULAR EPITHELIAL CELLS, WITH ELEVATED INCORPORATION OF ALPHA-SMA AND REORGANIZATION OF FOCAL ADHESIONS. THIS LEADS TO EMT, AS EVIDENCED BY A DECREASE IN E-CADHERIN EXPRESSION. (BOTTOM) FLUORESCENCE SIGNAL SHOWING THE DECREASE IN E-CADHERIN (LEFT) AND INCREASE IN ALPHA-SMA (RIGHT) IN KIDNEY...
UNIVERSITY OF SOUTHAMPTON IMAGE: GRAPHIC SUMMARY OF FINDINGS CREDIT: UNIVERSITY OF SOUTHAMPTON Research has found that prescriptions of non-steroidal anti-inflammatory drugs (NSAIDs) reduced over the two years before the pandemic. However, they were still being given to some people at high risk of kidney damage. The study was led by Dr Simon Fraser, Associate Professor of...
by Radboud University Kidney sections from healthy control (left) and COVID-19 patient (right). Scar tissue is blue. Credit: Jitske Jansen and Bart Smeets, Radboudumc The coronavirus SARS-CoV-2 infects the kidneys and contributes to tissue scarring, as shown by researchers from the RWTH Uniklinik Aachen, Germany, and Radboudumc, The Netherlands. The developed scar tissue in the...
by Jane E. Dee, Yale University Credit: Unsplash/CC0 Public Domain In a new paper accepted for publication in the Journal of the American Society of Nephrology, researchers at Yale School of Medicine share findings that indicate that, for the first time, there is a potential renal targeted treatment for kidney injury caused by cisplatin, a widely used...
by Ludwig Maximilian University of Munich Immunfluorescence of mononuclear phagocytes in the murine kidney. Credit: Barbara Schraml, Stephan Rambichler; LMU The immune system is highly complex. For example, a particular class of cells called mononuclear phagocytes (MNPs) plays important roles in the uptake and disposal of damaged cells, the elimination of invasive pathogens and other foreign...
by Kristina Sauerwein, Washington University in St. Louis Credit: Pixabay/CC0 Public Domain Research continues to mount indicating that many people who’ve had COVID-19 go on to suffer a range of adverse conditions months after their initial infections. A deep dive into federal health data adds to those concerns, pointing to a significant decline in kidney function among...
