In a study of patients with chronic kidney disease (CKD), persistent substance use—especially of hard illicit drugs—was linked with higher risks of CKD progression and early death. The findings appear in an upcoming issue of the Clinical Journal of the American Society of Nephrology (CJASN). CKD is common in the United States, and affected patients are at higher risk for poor...
Tag: <span>Kidney disease</span>
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New compound stops progressive kidney disease in its tracks
Progressive kidney diseases, whether caused by obesity, hypertension, diabetes, or rare genetic mutations, often have the same outcome: The cells responsible for filtering the blood are destroyed. Reporting in Science, a team led by researchers from the Broad Institute of MIT and Harvard, Brigham and Women’s Hospital, and Harvard Medical School describes a new approach to...
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Study provides insights on immune cells involved in kidney disease
Researchers have uncovered new information on cells involved in the body’s immune response following kidney injury. The findings, which appear in an upcoming issue of the Journal of the American Society of Nephrology (JASN), may lead to new strategies to help protect individuals’ kidney health. Dendritic cells are a type of immune cell thought to form...
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Poor sleep hastens progression of kidney disease
People with chronic kidney disease may be especially vulnerable to the deleterious effects of poor sleep, according to a new paper published in the Journal of the American Society of Nephrology. Chronic kidney disease is characterized by gradual loss of kidney function over time, and may eventually lead to kidney failure, leading patients to undergo dialysis...
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Steroid treatment for type of kidney disease associated with increased risk for serious infections
Among patients with IgA nephropathy and excess protein in their urine, treatment with pills of the steroid methylprednisolone was associated with an unexpectedly large increase in the risk of serious adverse events, primarily infections, according to a study published by JAMA. IgA nephropathy is a kidney disease that occurs when the antibody immunoglobulin A (IgA) lodges...
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Diabetes study raises treatment hope for kidney disease patients
Scientists have identified a key molecule linked to kidney disease in people with diabetes. Blocking the protein prevents kidney damage associated with diabetes in rats and mice, the study also found. The findings shed light on the causes of this common diabetes complication and could lead to new therapies, researchers say. Diabetes results in high levels...
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Highly prevalent gene variants in minority populations cause kidney disease
Preclinical study is first proof-of-concept to pave way for development of new therapeutics Representative images of kidney tissue from APOL1-G1 and APOL1-G2 mice, showing severe scarring of the kidney filter. African Americans have a heightened risk of developing chronic and end-stage kidney disease. This association has been attributed to two common genetic variants — named...
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Protein deficiency may explain kidney disease
Chronic kidney disease affects millions of people in the United States each year. New research points to a circulating protein that may be responsible for the decline in kidney function. New research suggests that the Klotho protein may be responsible for chronic kidney disease. The Greek goddess Klotho was responsible for spinning the thread of...