JOHNS HOPKINS MEDICINE In a new study looking at the long-term effects of hospitalized patients who have acute kidney injury (AKI), a sudden but temporary loss of kidney function, Johns Hopkins Medicine researchers found that higher levels of certain biomarkers in urine and blood can predict a patient’s risk of developing chronic kidney disease (CKD)....
Tag: <span>Kidney disease</span>
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Scientists identify role of key metabolism enzyme in kidney disease
By Paul McClure March 26, 2023 Scientists have identified the role that an enzyme found in every single living cell plays in the development of kidney disease Depositphotos Scientists have identified the role an enzyme, crucial to the body’s metabolism, plays in the development of kidney disease, opening the door to new methods of prevention...
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Scientists uncover protective role of NAD maintenance in kidney disease
by Perelman School of Medicine at the University of Pennsylvania Integrated metabolomics and transcriptomics data analysis of human kidney samples. a, Total of 50 human kidney samples were collected for metabolomics analysis; including healthy controls (n = 25) and patients with KD (n = 25). b, Volcano plot of metabolites showing significant changes in human diseased kidneys. The x axis shows log2 fold change (log2FC)....
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Scientists pave way for potential cure for severe kidney disease disproportionately affecting Black individuals
by Jacqueline Mitchell, Beth Israel Deaconess Medical Center Credit: Pixabay/CC0 Public Domain Today in the United States, about two out of every 1,000 people live with kidney failure. For every one white person who develops the disease, three Black people do. Kidney failure, also known as end-stage renal failure or end-stage kidney disease, is the irreversible...
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World first test to detect diabetics at risk of kidney disease
by Monash University Credit: Pixabay/CC0 Public Domain In a world first international study led by Monash University researchers in Australia, the genetic markers for people with diabetes at risk of developing kidney disease have been identified. The study opens the way for the development of a test that could predict those adults with Type 1 diabetes at...
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Drug discovery offers potential treatment for common kidney disease
by University of Edinburgh Scanned images of whole kidneys comparing a healthy contralateral mouse kidney with a kidney after ischemia-reperfusion injury (IRI), with red staining indicative of fibrosis. Credit: Science Translational Medicine (2022). DOI: 10.1126/scitranslmed.abf5074 A serious condition that can cause the kidneys to suddenly stop working could be treated with existing medicines, a new study shows. In...
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Early diagnosis tool for childhood kidney disease
by University of Tokyo Location of three biomarkers (MGAM, MUC1, CD9) in kidney tissue shown as green, blue or red by tissue staining. These biomarkers are situated in different cellular compartments in different segments of the nephron. Credit: 2022 Takizawa et al. Early diagnosis of chronic kidney disease (CKD) is key to managing progression of...
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Metabolism may be key to future treatment of kidney diseases
by Aarhus University Credit: Pixabay/CC0 Public Domain Can you eat your way out of a kidney disease? Perhaps you can—according to a new study from Aarhus University. In the study, Associate Professor Markus Rinschen from Aarhus Institute of Advanced Studies and Department of Biomedicine has shown that the intake of the amino acid lysine, an over-the-counter...
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Study results challenge current thinking about autosomal dominant polycystic kidney disease
AMERICAN SOCIETY OF NEPHROLOGY Highlight New research indicates that the polycystin-2 protein in cells’ endoplasmic reticulum is important for maintaining kidney health, and its lack can contribute to autosomal dominant polycystic kidney disease. Washington, DC (July 12, 2022) — Autosomal dominant polycystic kidney disease (ADPKD) is a common genetic condition that can lead to kidney failure...
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New research maps possible molecular origins of kidney disease
by University of Pennsylvania Credit: Pixabay/CC0 Public Domain After mapping the genetic underpinning of kidney function in 1.5 million people and about 60,000 kidney cells that are the microscopic mechanisms of gene regulation, researchers at the Perelman School of Medicine at the University of Pennsylvania found that more than 500 genes likely contribute to kidney...