by University of Pennsylvania Credit: Pixabay/CC0 Public Domain After mapping the genetic underpinning of kidney function in 1.5 million people and about 60,000 kidney cells that are the microscopic mechanisms of gene regulation, researchers at the Perelman School of Medicine at the University of Pennsylvania found that more than 500 genes likely contribute to kidney...
by Flinders University Credit: Pixabay A new method for early detection of chronic kidney disease, which affects an estimated 9% of the world’s population, has been shown to have potential to service rural and remote patients and communities with limited medical services. An affordable and portable biosensor device put to the test by Flinders University...
Jonathan Gardner Senior Reporter Eli Lilly & Co. Dive Brief: Eli Lilly and Boehringer Ingelheim’s drug Jardiance kept clinical trial participants with kidney disease from needing dialysis or a transplant, the companies announced Wednesday, a finding that cements the diabetes pill’s potential as a treatment for a wider array of metabolic diseases. The trial was expected...
by Federico Graciano, Duke-NUS Medical School Graphical abstract. Credit: Journal of the American Society of Nephrology (2022). DOI: 10.1681/asn.2021040577 A treatment strategy using an antibody that inhibits a cell signaling protein called interleukin-11 (IL-11) could lead to new hope for people with a debilitating genetic kidney disease called Alport syndrome. Scientists from Duke-NUS Medical School, Singapore, reported...
by Michael Addelman, University of Manchester Graphical abstract. Credit: DOI: 10.1093/cvr/cvab357 A study led by University of Manchester and Manchester University NHS Foundation Trust (MFT) researchers has revealed that obesity is likely to cause an increased risk of kidney disease. Published in Cardiovascular Research, the findings—based on big data and a unique kidney tissue resource funded by Kidney Research UK—suggest...
by Michaela Kane, Duke University Podocyte Models. Credit: Duke University Biomedical engineers at Duke University have developed a method to study how key cells in the kidneys become injured and deformed. The new model has revealed a significant mechanism behind severe kidney disease and pointed toward early disease biomarkers and potential therapeutic interventions. The study...
by Medical Journal of Australia Credit: Robina Weermeijer/Unsplash People over 65 years of age with stage 4 chronic kidney disease (CKD) were more likely to die than to experience kidney failure, suggesting that more people die with CKD rather than directly because of CKD, according to research published today by the Medical Journal of Australia. Professor...
by Australian National University Graphical abstract. Credit: DOI: 10.1016/j.xcrm.2021.100469 For the first time researchers have identified a gene which shows the kidney has its own way of resisting damage. The finding has major implications—especially for Indigenous people with kidney diseases such as Tiwi Islanders. The study, published in Cell Reports Medicine, sequenced the genome of patients with autoimmune...
by Kyoto University A new study led by ASHBi Professor Motoko Yanagita finds the suppression of two molecules, CD153 and CD30, expressed on immune cells mitigates the progression of kidney disease. Credit: Kyoto University Despite nearly two million people dying of acute kidney injury every year, and tens of millions more needing treatment, no effective...
by Noah Fromson, University of Michigan Credit: CC0 Public Domain Cerebral palsy and kidney disease can be deeply intertwined. In childhood, the effects of the neurodevelopmental condition—like decreased physical activity and urologic dysfunction—are risk factors for kidney disease. The adverse relationship continues through adulthood as those with cerebral palsy often have high blood pressure, another risk for developing kidney problems. What’s more, a recent Michigan...
