by Bill Snyder, Vanderbilt University EGFR was highly expressed in kidney myofibroblasts from both male and female patients. Credit: Nature Communications (2023). DOI: 10.1038/s41467-023-43226-xResearchers at Vanderbilt University Medical Center for the first time have shown that activation of the epidermal growth factor receptor (EGFR) is essential for the development of kidney fibrosis, tissue scarring following injury...
by Nagoya University Enzyme-regulating macrophages found in both humans and mice open the door to translating findings in mice into human therapies. Credit: Issey Takahashi Researchers at Nagoya University in Japan have identified two enzymes that are involved in macrophage polarization, one of the key factors affecting fibrosis. The group’s findings, reported in Cell Death &...
by Virginia Tech Webster Santos, the Cliff and Agnes Lilly Faculty Fellow in the Virginia Tech College of Science and a professor in the Department of Chemistry, in his lab at Davidson Hall. Credit: Greg Atkins, Virginia Tech Webster Santos is determined to find a way to halt kidney fibrosis, a condition caused by persistent...
SMOC2 staining (red) in a sample from a patient with kidney fibrosis. When the kidneys – vital organs for filtering the body’s entire blood supply – become injured, it can set in motion an unfortunate chain of events that leads to a decline in health. Sometimes, in response to chronic injury, the body begins...
